α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate

Base Information

Chemical Name:α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate
CAS No.:124126-66-5
Molecular Formula:C₅₁H₇₅N₁₁O₁₄
Molecular Weight:1066.22
Hs Code.:

α-tert-butyl 4-amino-4-deoxy-N<sup>10</sup>-methylpteroyltetraglutamate

Synonyms:α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate

Chemical Property:

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Technology Process of α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate

There total 4 articles about α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 45120-30-7
L-glutamic acid α-tert-butyl ester

: 124126-66-5
α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 10percent Na₂CO₃ / dioxane / 20 h / 24 °C

2: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

3: KH poliamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

With piperidine; 4-methyl-morpholine; dmap; KH poliamide resin; sodium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00164a038

Reference yield:

: 19741-14-1
4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

: 124126-66-5
α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / dimethylsulfoxide; dimethylformamide / 30 h / 0 °C

2: KH poliamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

With piperidine; 4-methyl-morpholine; dmap; KH poliamide resin; trifluoroacetic acid; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00164a038

Reference yield:

: 84793-07-7
Fmoc-Glu-OtBu

: 124126-66-5
α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate

Guidance literature:: Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

2: KH poliamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

With piperidine; 4-methyl-morpholine; dmap; KH poliamide resin; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm00164a038