Bis(trimethylsilyl)-6-hydroxy-3,9-dimethoxy-3,6,9-triphenylundeca-1,4,7,10-tetrayne

Base Information

• Chemical Name: Bis(trimethylsilyl)-6-hydroxy-3,9-dimethoxy-3,6,9-triphenylundeca-1,4,7,10-tetrayne
• CAS No.: 349546-65-2
• Molecular Formula: C₃₇H₄₀O₃Si₂
• Molecular Weight: 588.894
• Mol file: 349546-65-2.mol

Synonyms:Bis(trimethylsilyl)-6-hydroxy-3,9-dimethoxy-3,6,9-triphenylundeca-1,4,7,10-tetrayne

Chemical Property of Bis(trimethylsilyl)-6-hydroxy-3,9-dimethoxy-3,6,9-triphenylundeca-1,4,7,10-tetrayne

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bis(trimethylsilyl)-6-hydroxy-3,9-dimethoxy-3,6,9-triphenylundeca-1,4,7,10-tetrayne

There total 6 articles about Bis(trimethylsilyl)-6-hydroxy-3,9-dimethoxy-3,6,9-triphenylundeca-1,4,7,10-tetrayne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

benzoyl chloride (98-88-4) + 1-trimethylsilyl-3-phenyl-3-methoxypenta-1,4-diyne (165055-35-6) → Bis(trimethylsilyl)-6-hydroxy-3,9-dimethoxy-3,6,9-triphenylundeca-1,4,7,10-tetrayne (349546-65-2)

Guidance literature:

1-trimethylsilyl-3-phenyl-3-methoxypenta-1,4-diyne; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

benzoyl chloride; In tetrahydrofuran; hexane; at 20 ℃; for 3h; Further stages.;

DOI:10.1002/1521-3765(20010316)7:6<1202::AID-CHEM1202>3.3.CO;2-I

Reference yield: 77.0%

benzoyl chloride (98-88-4) + 1-trimethylsilyl-3-(4-methoxyphenyl)-3-methoxypenta-1,4-diyne (801287-33-2) → Bis(trimethylsilyl)-6-hydroxy-3,9-dimethoxy-3,6,9-triphenylundeca-1,4,7,10-tetrayne (349546-65-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃;

DOI:10.1016/j.tet.2004.07.052

Reference yield:

1‐(4‐methoxyphenyl)‐3‐(trimethylsilyl)prop‐2‐yn‐1‐one (99048-48-3) → Bis(trimethylsilyl)-6-hydroxy-3,9-dimethoxy-3,6,9-triphenylundeca-1,4,7,10-tetrayne (349546-65-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / EtMgBr / tetrahydrofuran; diethyl ether / 17 h / 20 °C

2: n-BuLi / tetrahydrofuran; hexane; dimethylsulfoxide / 3 h / -20 - 20 °C

3: 77 percent / n-BuLi / tetrahydrofuran; hexane / 20 °C

With n-butyllithium; ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; hexane; dimethyl sulfoxide;

DOI:10.1016/j.tet.2004.07.052

upstream raw materials:

benzoyl chloride

1-trimethylsilyl-3-phenyl-3-methoxypenta-1,4-diyne

1-trimethylsilyl-3-(4-methoxyphenyl)-3-methoxypenta-1,4-diyne

1‐(4‐methoxyphenyl)‐3‐(trimethylsilyl)prop‐2‐yn‐1‐one

Downstream raw materials:

Bis(trimethylsilyl)-3,6,9-trimethoxy-3,6,9-triphenylundeca-1,4,7,10-tetrayne

3,6,9-Trimethoxy-3,6,9-triphenylundeca-1,4,7,10-tetrayne