2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanol

Base Information

Chemical Name:2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanol
CAS No.:1451453-90-9
Molecular Formula:C₂₅H₄₁N₃O₆
Molecular Weight:479.617
Hs Code.:

Synonyms:2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanol

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Chemical Property of 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanol

Chemical Property:

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Technology Process of 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanol

There total 3 articles about 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 37169-25-8
methyl 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanoate

: 1451453-90-9
2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanol

Guidance literature:: With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; at 20 ℃; for 16h;
DOI:10.1021/jm400294w

Reference yield:

: 2018-66-8
Z-Leu-OH

: 1451453-90-9
2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 16 h / 20 °C

With sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm400294w

Reference yield:

: 2389-48-2
N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

: 1451453-90-9
2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanol

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate; lithium chloride / tetrahydrofuran; ethanol / 16 h / 20 °C

With sodium tetrahydroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm400294w