methyl 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanoate

Base Information

• Chemical Name: methyl 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanoate
• CAS No.: 37169-25-8
• Molecular Formula: C₂₆H₄₁N₃O₇
• Molecular Weight: 507.627

Synonyms:methyl 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanoate

Chemical Property of methyl 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanoate

Chemical Property:

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Technology Process of methyl 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanoate

There total 2 articles about methyl 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Z-Leu-OH (2018-66-8) + N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride (2389-48-2) → methyl 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanoate (37169-25-8)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm400294w

Reference yield:

Z-Leu-ONp (1738-87-0) + N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride (2389-48-2) → methyl 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanoate (37169-25-8)

Guidance literature:

With triethylamine;

DOI:10.1039/P19720001407

Reference yield: 97.0%

methyl 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanoate (37169-25-8) → 2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanol (1451453-90-9)

Guidance literature:

With sodium tetrahydroborate; lithium chloride; In tetrahydrofuran; ethanol; at 20 ℃; for 16h;

DOI:10.1021/jm400294w

upstream raw materials:

Z-Leu-ONp

N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride

Z-Leu-OH

Downstream raw materials:

2S-(2S-benzyloxycarbonylamino-4-methylpentanamido)-6-(tert-butoxycarbonylamino)hexanol

trans-5S-(2'S-benzyloxycarbonylamino-4'-methylpentanamido)-7-(phenylsulfonyl)hept-6-en-1-tert-butoxycarbonylamine

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