N-succinimidyl 4-(tri-n-butylstannyl)benzoate

Base Information

• Chemical Name: N-succinimidyl 4-(tri-n-butylstannyl)benzoate
• CAS No.: 107759-58-0
• Molecular Formula: C23H35 N O4 Sn
• Molecular Weight: 508.245
• Mol file: 107759-58-0.mol

Synonyms:2,5-Pyrrolidinedione,1-[[4-(tributylstannyl)benzoyl]oxy]- (9CI); N-Succinimidyl-p-(tributylstannyl)benzoate

Chemical Property of N-succinimidyl 4-(tri-n-butylstannyl)benzoate

Chemical Property:

• Vapor Pressure: 5.95E-11mmHg at 25°C
• Boiling Point: 520.9°Cat760mmHg
• Flash Point: 268.9°C
• PSA: 63.68000
• Density: g/cm³
• LogP: 4.33270

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Succinimidyl-4-(tributylstannyl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Succinimidyl-4-(tributylstannyl)benzoate is used as a reactant in the synthesis of urea-based GCPII inhibitors.

Technology Process of N-succinimidyl 4-(tri-n-butylstannyl)benzoate

There total 7 articles about N-succinimidyl 4-(tri-n-butylstannyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2,5-dioxopyrrolidin-1-yl 4-iodobenzoate (39028-25-6) + bis(tri-n-butyltin) (813-19-4) → 4-(tributylstannyl)benzoic acid N-hydroxyl succinimidyl ester (107759-58-0)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; for 24h; Inert atmosphere; Reflux;

Reference yield:

tri-n-butylstannyl 4-(tri-n-butylstannyl)benzoate (107759-57-9) → 4-(tributylstannyl)benzoic acid N-hydroxyl succinimidyl ester (107759-58-0)

Guidance literature:

With acetic acid; In tetrahydrofuran;

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 4-(tri-n-butylstannyl)benzoic acid → 4-(tributylstannyl)benzoic acid N-hydroxyl succinimidyl ester (107759-58-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2020.115319

upstream raw materials:

tri-n-butylstannyl 4-(tri-n-butylstannyl)benzoate

2,5-dioxopyrrolidin-1-yl 4-iodobenzoate

bis(tri-n-butyltin)

4-iodobenzoic acid ethyl ester

Downstream raw materials:

(4-((2,5-Dioxopyrrolidin-1-yloxy)carbonyl)phenyl)(thiophen-2-yl)iodonium trifluoroacetate

[¹²⁴l]-N-hydroxysuccinimide benzoate