diethyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate

Base Information

Chemical Name:diethyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate
CAS No.:1437798-91-8
Molecular Formula:C₂₂H₂₇NO₆
Molecular Weight:401.459
Hs Code.:

Synonyms:diethyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate

Chemical Property:

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Technology Process of diethyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate

There total 4 articles about diethyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 50845-77-7
N-(4-methoxy)phenylglycine ethyl ester

: 141-97-9
ethyl acetoacetate

: 123-54-6,81235-32-7
acetylacetone

: 1437798-91-8
diethyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate

Guidance literature:: With oxygen; copper(II) bis(trifluoromethanesulfonate); In toluene; at 60 ℃; for 12h; under 760.051 Torr; Green chemistry;
DOI:10.1021/acs.joc.6b01736

Reference yield:

: 924-44-7
glyoxylic acid ethyl ester

: 20010-38-2
4-(4-methoxyphenyl)imino-3-pentene-2-one

: 141-97-9
ethyl acetoacetate

: 1437798-91-8
diethyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate

Guidance literature:: at 20 ℃;
DOI:10.1016/j.tet.2013.04.006

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 1437798-91-8
diethyl 5-acetyl-1-(4-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: montmorillonite K-10 / 6 h / 20 °C / Green chemistry

2: 20 °C

With montmorillonite K-10;
DOI:10.1016/j.tet.2013.04.006