Technology Process of (-)-8-(5,8-Dichloro-1,2,3,4-tetrahydro-2-naphthyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one
There total 7 articles about (-)-8-(5,8-Dichloro-1,2,3,4-tetrahydro-2-naphthyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one; 5,8-dichloro-3,4-dihydro-1H-naphthalen-2-one;
With
4 A molecular sieve;
In
toluene;
Heating;
With
hydrogenchloride; sodium cyanoborohydride;
In
tetrahydrofuran; ethanol;
at 20 ℃;
for 16h;
pH=4.5;
Further stages.;
DOI:10.1021/jm991129q
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 37 percent / triethyloxonium tetrafluoroborate / CH2Cl2 / 0 - 20 °C
2.1: 75 percent / H2O / 2.5 h / 240 °C / 12751.3 Torr
3.1: 99 percent / sodium borohydride / ethanol; H2O / 0.5 h / Heating
4.1: 96 percent / p-toluenesulfonic acid / toluene / Heating
5.1: 88 percent / N-methylmorpholine N-oxide; osmium tetroxide / acetone; H2O; 2-methyl-propan-2-ol / 20 h / 20 °C
6.1: 22 percent / p-toluenesulfonic acid / toluene / 3 h / Heating
7.1: 4 Angstroem molecular sieves / toluene / Heating
7.2: 47 percent / sodium cyanoborohydride; HCl / tetrahydrofuran; ethanol / 16 h / 20 °C / pH 4.5
With
sodium tetrahydroborate; osmium(VIII) oxide; 4 A molecular sieve; triethyloxonium fluoroborate; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide;
In
ethanol; dichloromethane; water; acetone; toluene; tert-butyl alcohol;
1.1: Ring expansion / 2.1: Decarboxylation / 3.1: Reduction / 4.1: Dehydration / 5.1: Dihydroxylation / 6.1: Rearrangement / 7.1: Condensation / 7.2: Reduction;
DOI:10.1021/jm991129q
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 99 percent / sodium borohydride / ethanol; H2O / 0.5 h / Heating
2.1: 96 percent / p-toluenesulfonic acid / toluene / Heating
3.1: 88 percent / N-methylmorpholine N-oxide; osmium tetroxide / acetone; H2O; 2-methyl-propan-2-ol / 20 h / 20 °C
4.1: 22 percent / p-toluenesulfonic acid / toluene / 3 h / Heating
5.1: 4 Angstroem molecular sieves / toluene / Heating
5.2: 47 percent / sodium cyanoborohydride; HCl / tetrahydrofuran; ethanol / 16 h / 20 °C / pH 4.5
With
sodium tetrahydroborate; osmium(VIII) oxide; 4 A molecular sieve; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide;
In
ethanol; water; acetone; toluene; tert-butyl alcohol;
1.1: Reduction / 2.1: Dehydration / 3.1: Dihydroxylation / 4.1: Rearrangement / 5.1: Condensation / 5.2: Reduction;
DOI:10.1021/jm991129q
![1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one](/Databaselist/images/loading.webp)
