tert-butyl 5-((5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenylamino)methyl)pyrazin-2-ylcarbamate

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Chemical Name:tert-butyl 5-((5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenylamino)methyl)pyrazin-2-ylcarbamate
CAS No.:1315380-71-2
Molecular Formula:C₃₂H₄₀F₃N₇O₃
Molecular Weight:627.71
Hs Code.:

Synonyms:tert-butyl 5-((5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenylamino)methyl)pyrazin-2-ylcarbamate

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Chemical Property of tert-butyl 5-((5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenylamino)methyl)pyrazin-2-ylcarbamate

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Technology Process of tert-butyl 5-((5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenylamino)methyl)pyrazin-2-ylcarbamate

There total 3 articles about tert-butyl 5-((5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenylamino)methyl)pyrazin-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1315469-94-3
N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

: 369638-69-7
tert-butyl (5-(bromomethyl)pyrazin-2-yl)carbamate

: 1315380-71-2
tert-butyl 5-((5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenylamino)methyl)pyrazin-2-ylcarbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

Reference yield:

: 5521-55-1
2-methylpyrazin-5-carboxylic acid

: 1315380-71-2
tert-butyl 5-((5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenylamino)methyl)pyrazin-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; diphenyl phosphoryl azide / toluene / 6 h / Reflux

2: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 4 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C

With N-Bromosuccinimide; diphenyl phosphoryl azide; potassium carbonate; triethylamine; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 369638-68-6
tert-butyl (5-methylpyrazin-2-yl)carbamate

: 1315380-71-2
tert-butyl 5-((5-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamido)-2-methylphenylamino)methyl)pyrazin-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 4 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C

With N-Bromosuccinimide; potassium carbonate; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; N,N-dimethyl-formamide;