4-((4-ethylpiperazin-1-yl)methyl)-N-(3-((4-methoxy-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide

Base Information

Chemical Name:4-((4-ethylpiperazin-1-yl)methyl)-N-(3-((4-methoxy-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide
CAS No.:1315466-65-9
Molecular Formula:C₃₇H₄₉F₃N₆O₃Si
Molecular Weight:710.915
Hs Code.:

4-((4-ethylpiperazin-1-yl)methyl)-N-(3-((4-methoxy-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide

Synonyms:4-((4-ethylpiperazin-1-yl)methyl)-N-(3-((4-methoxy-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide

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Chemical Property of 4-((4-ethylpiperazin-1-yl)methyl)-N-(3-((4-methoxy-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide

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Technology Process of 4-((4-ethylpiperazin-1-yl)methyl)-N-(3-((4-methoxy-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide

There total 4 articles about 4-((4-ethylpiperazin-1-yl)methyl)-N-(3-((4-methoxy-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1315381-30-6
4-methoxy-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

: 1315469-94-3
N-(3-amino-4-methylphenyl)-4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzamide

: 1315466-65-9
4-((4-ethylpiperazin-1-yl)methyl)-N-(3-((4-methoxy-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In 1,4-dioxane; at 20 ℃;

Reference yield:

: 958230-19-8
4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

: 1315466-65-9
4-((4-ethylpiperazin-1-yl)methyl)-N-(3-((4-methoxy-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: sodium / 8 h / 60 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / 1,4-dioxane / 20 °C

With sodium; sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 1315381-29-3
4-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde

: 1315466-65-9
4-((4-ethylpiperazin-1-yl)methyl)-N-(3-((4-methoxy-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)methyl)amino)-4-methylphenyl)-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium / 8 h / 60 °C

2: acetic acid; sodium tris(acetoxy)borohydride / 1,4-dioxane / 20 °C

With sodium; sodium tris(acetoxy)borohydride; acetic acid; In 1,4-dioxane;