Bromo-PEG2-azide

Base Information

• Chemical Name: Bromo-PEG2-azide
• CAS No.: 530151-56-5
• Molecular Formula: C₆H₁₂BrN₃O₂
• Molecular Weight: 238.084
• Mol file: 530151-56-5.mol

Synonyms:1-(2-azidoethoxy)-2-(2-bromoethoxy)ethane

Chemical Property of Bromo-PEG2-azide

Chemical Property:

• Solubility.: Soluble in DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bromo-PEG2-azide 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Bromo-PEG2-azide is a heterobifunctional crosslinking reagent.. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The bromide (Br) is a good leaving group for nucleophilic substitution.

Technology Process of Bromo-PEG2-azide

There total 2 articles about Bromo-PEG2-azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-[2-(2-azidoethoxy)ethoxy]ethanol (86520-52-7) → 1-(2-azidoethoxy)-2-(2-bromoethoxy)ethane (530151-56-5)

Guidance literature:

With phosphorus tribromide; In tetrahydrofuran; Inert atmosphere;

DOI:10.1016/j.bmc.2008.10.005

Reference yield:

carbon tetrabromide (558-13-4) + 2-[2-(2-azidoethoxy)ethoxy]ethanol (86520-52-7) → 1-(2-azidoethoxy)-2-(2-bromoethoxy)ethane (530151-56-5)

Guidance literature:

With triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield: 88.0%

1-(2-azidoethoxy)-2-(2-bromoethoxy)ethane (530151-56-5) + 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (214360-76-6) → 2-(3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 24h;

DOI:10.1002/anie.201804716

upstream raw materials:

2-[2-(2-azidoethoxy)ethoxy]ethanol

carbon tetrabromide

Downstream raw materials:

C₁₁H₂₂N₄O₅