N-hydroxysuccinimide ester of 7-carboxymethoxy-4-phenylcoumarin

Base Information

• Chemical Name: N-hydroxysuccinimide ester of 7-carboxymethoxy-4-phenylcoumarin
• CAS No.: 270596-09-3
• Molecular Formula: C₂₁H₁₅NO₇
• Molecular Weight: 393.353
• Mol file: 270596-09-3.mol

Synonyms:N-hydroxysuccinimide ester of 7-carboxymethoxy-4-phenylcoumarin

Chemical Property of N-hydroxysuccinimide ester of 7-carboxymethoxy-4-phenylcoumarin

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-hydroxysuccinimide ester of 7-carboxymethoxy-4-phenylcoumarin

There total 3 articles about N-hydroxysuccinimide ester of 7-carboxymethoxy-4-phenylcoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 7-carboxymethoxy-4-phenylcoumarin (130181-72-5) → N-hydroxysuccinimide ester of 7-carboxymethoxy-4-phenylcoumarin (270596-09-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1007/BF02282506

Reference yield:

7-hydroxy-4-phenylcoumarin (2555-30-8) → N-hydroxysuccinimide ester of 7-carboxymethoxy-4-phenylcoumarin (270596-09-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / K₂CO₃; KI / ethanol / 50 - 56 °C

2: 95 percent / 5 percent NaHCO₃ / ethanol / Heating

3: 79 percent / DCC / tetrahydrofuran / 1 h / 0 °C

With sodium hydrogencarbonate; potassium carbonate; dicyclohexyl-carbodiimide; potassium iodide; In tetrahydrofuran; ethanol; 1: Alkylation / 2: saponification / 3: Condensation;

DOI:10.1007/BF02282506

Reference yield:

ethyl 2-((2-oxo-4-phenyl-2H-chromen-7-yl)oxy)acetate (5614-80-2) → N-hydroxysuccinimide ester of 7-carboxymethoxy-4-phenylcoumarin (270596-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / 5 percent NaHCO₃ / ethanol / Heating

2: 79 percent / DCC / tetrahydrofuran / 1 h / 0 °C

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; 1: saponification / 2: Condensation;

DOI:10.1007/BF02282506

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

7-carboxymethoxy-4-phenylcoumarin

7-hydroxy-4-phenylcoumarin

ethyl 2-((2-oxo-4-phenyl-2H-chromen-7-yl)oxy)acetate