2555-30-8

Basic information

• Product Name: 7-HYDROXY-4-PHENYLCOUMARIN 97
• Synonyms: 7-HYDROXY-4-PHENYLCOUMARIN 97;7-Hydroxy-4-phenyl-2H-chromen-2-one;7-Hydroxy-4-phenylcoumarin;7-Hydroxy-4-phenylcoumarin 97%
• CAS NO: 2555-30-8
• Molecular Formula: C₁₅H₁₀O₃
• Molecular Weight: 238.24
• Product Categories: Coumarin;Building Blocks;Coumarins;Heterocyclic Building Blocks
• Mol File: 2555-30-8.mol
• Article Data: 87

Chemical Properties

• Melting Point: 248-252 °C(lit.)
• Boiling Point: 458.3 °C at 760 mmHg
• Flash Point: 203.3 °C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 5.11E-09mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 7-HYDROXY-4-PHENYLCOUMARIN 97(CAS DataBase Reference)
• NIST Chemistry Reference: 7-HYDROXY-4-PHENYLCOUMARIN 97(2555-30-8)
• EPA Substance Registry System: 7-HYDROXY-4-PHENYLCOUMARIN 97(2555-30-8)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 26-27-36/37/39-37/39-45
• WGK Germany: 3
• Hazardous Substances Data: 2555-30-8(Hazardous Substances Data)

Usage

General Description

7-HYDROXY-4-PHENYLCOUMARIN 97 is a chemical compound with the molecular formula C16H12O3. It is a coumarin derivative that is commonly used in scientific research and as a fluorescent dye in biochemical assays. 7-HYDROXY-4-PHENYLCOUMARIN 97 exhibits strong fluorescence when excited by ultraviolet light, making it useful in various fluorescence-based applications. It is also known for its potential therapeutic properties, including antioxidant, anti-inflammatory, and anti-cancer activities. 7-HYDROXY-4-PHENYLCOUMARIN 97 is a versatile compound with potential applications in both research and medical fields, making it a valuable chemical for various scientific and industrial purposes.

InChI:InChI=1/C15H10O3/c16-11-6-7-12-13(10-4-2-1-3-5-10)9-15(17)18-14(12)8-11/h1-9,16H

Upstream product

• 562835-40-9 7-hydroxy-4-phenyl-chromen-2-one-imine 
• 16299-27-7 2-oxo-4-phenyl-2H-chromen-7-yl acetate 
• 853926-01-9 7-hydroxy-2-oxo-4-phenyl-2H-chromene-3-carboxylic acid 
• 131-56-6 2.4-dihydroxybenzophenone 
• 4071-85-6 trimetylsilylketene 
• 637-44-5 phenylpropyolic acid 
• 108-46-3 recorcinol 
• 911217-72-6 C₁₇H₁₁F₁₃O₃ 
• 2555-31-9 7-methoxy-4-phenyl-2H-chromen-2-one 
• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 71-43-2 benzene 
• 587-85-9 diphenylmercury(II) 
• 94739-96-5 7-furoyloxy-4-phenylcoumarin 
• 94739-94-3 7-hexanoyloxy-4-phenylcoumarin 

Downstream Products

• 108979-94-8 7-ethoxy-4-phenyl-2H-chromen-2-one 
• 110876-08-9 7-(benzyloxy)-4-phenyl-2H-chromen-2-one 
• 94739-93-2 2-oxo-4-phenyl-2H-chromen-7-ylbenzoate 
• 6275-80-5 (±)-7-hydroxy-4-phenyl-3,4-dihydrocoumarin 
• 175603-19-7 3-bromo-7-hydroxy-4-phenylcoumarin 
• 482-82-6 nordalbergin 
• 139286-96-7 3-Hydroxy-2-[(7-hydroxy-2-oxo-4-phenyl-2H-chromen-8-ylmethyl)-amino]-propionic acid 
• 139286-95-6 2-[(7-Hydroxy-2-oxo-4-phenyl-2H-chromen-8-ylmethyl)-amino]-3-phenyl-propionic acid 
• 94739-95-4 7-(β,β-dimethylacryloxy)-4-phenylcoumarin 
• 94739-94-3 7-hexanoyloxy-4-phenylcoumarin 
• 139286-94-5 2-[(7-Hydroxy-2-oxo-4-phenyl-2H-chromen-8-ylmethyl)-amino]-3-methyl-butyric acid 
• 80494-06-0 8-diethanolaminomethyl-7-hydroxy-4-phenyl coumarin 
• 139286-92-3 N-(7-hydroxy-4-phenyl-8-coumarinyl)glycine 
• 139286-93-4 2-[(7-Hydroxy-2-oxo-4-phenyl-2H-chromen-8-ylmethyl)-amino]-propionic acid 

Relevant articles and documents

Implementation of a spraying-assisted fine droplet formation-based simultaneous liquid-phase microextraction method for the determination of copper in clove extract samples

A simultaneous liquid-phase microextraction method was investigated as an alternative to the traditional dispersive liquid–liquid microextraction for the determination of copper. The potential of this approach is based on the simultaneous complexation and

2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases

We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as novel inhibitors of tumour-related CAs IX and XII. Substituents on C-3 and/or C-4 positions of the coumarin scaffold, and on the benzoxazole moiety, together with the length of the linker connecting both units were modified to obtain useful structure-activity relationships. CA inhibition studies revealed a good selectivity towards tumour-associated CAs IX and XII (K i within the mid-nanomolar range in most of the cases) in comparison with CAs I, II, IV, and VII (K i > 10 μM); CA IX was found to be slightly more sensitive towards structural changes. Docking calculations suggested that the coumarin scaffold might act as a prodrug, binding to the CAs in its hydrolysed form, which is in turn obtained due to the esterase activity of CAs. An increase of the tether length and of the substituents steric hindrance was found to be detrimental to in?vitro antiproliferative activities. Incorporation of a chlorine atom on C-3 of the coumarin moiety achieved the strongest antiproliferative agent, with activities within the low micromolar range for the panel of tumour cell lines tested.

Synthesis of C4-substituted coumarins via Pechmann condensation catalyzed by sulfamic acid. Insights into the reaction mechanism by HRMS analysis

A series of functionalized C4-substituted coumarins were synthesized by exploring the reaction of activated and non-activated phenols and β-ketoesters under solvent-free conditions in the presence of sulfamic acid as a Br?nsted acid catalyst. Fifteen exam