Bromo-(4-chloro-phenyl)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester

Base Information

Chemical Name:Bromo-(4-chloro-phenyl)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester
CAS No.:449780-21-6
Molecular Formula:C₁₅H₁₇BrClNO₃
Molecular Weight:374.662
Hs Code.:

Synonyms:Bromo-(4-chloro-phenyl)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester

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Chemical Property of Bromo-(4-chloro-phenyl)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester

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Technology Process of Bromo-(4-chloro-phenyl)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester

There total 2 articles about Bromo-(4-chloro-phenyl)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4-Chloro-phenyl)-oxo-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester

: 449780-21-6
Bromo-(4-chloro-phenyl)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester

Guidance literature:: (4-Chloro-phenyl)-oxo-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester; With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 0.5h;

With phosphorus tribromide; In dichloromethane; at 25 ℃; for 0.5h;
DOI:10.1021/jm0502135

Reference yield:

: 151670-13-2
(D)-1-(1-pyrrolidinyl)-2-hydroxy-1-propanone

: 449780-21-6
Bromo-(4-chloro-phenyl)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl chloride; DMF / CH₂Cl₂ / 0.5 h / Heating

1.2: Et₃N / CH₂Cl₂ / 0.5 h / 0 - 25 °C

2.1: NaBH₄ / tetrahydrofuran / 0.5 h / 0 °C

2.2: PBr₃ / CH₂Cl₂ / 0.5 h / 25 °C

With sodium tetrahydroborate; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0502135

Reference yield:

: 860780-49-0
3-ethyl-6-hydroxy-5,7-dipropyl-1,3-benzoxazol-2(3H)-one

: 449780-21-6
Bromo-(4-chloro-phenyl)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester

: (S)-(4-Chloro-phenyl)-(3-ethyl-2-oxo-5,7-dipropyl-2,3-dihydro-benzooxazol-6-yloxy)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester

Guidance literature:: 3-ethyl-6-hydroxy-5,7-dipropyl-1,3-benzoxazol-2(3H)-one; With lithium tert-butoxide; In tetrahydrofuran;

Bromo-(4-chloro-phenyl)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester; In tetrahydrofuran; at 0 ℃;
DOI:10.1021/jm0502135