(2R)-1-oxo-1-pyrrolidinylpropane-2-ol

Base Information

• Chemical Name: (2R)-1-oxo-1-pyrrolidinylpropane-2-ol
• CAS No.: 151670-13-2
• Molecular Formula: C7H13 N O2
• Molecular Weight: 143.186
• European Community (EC) Number: 826-715-5
• Nikkaji Number: J3.002.282C
• Mol file: 151670-13-2.mol

Synonyms:151670-13-2;(2R)-1-oxo-1-pyrrolidinylpropane-2-ol;Pyrrolidine, 1-[(2R)-2-hydroxy-1-oxopropyl]- (9CI);(2R)-2-hydroxy-1-pyrrolidin-1-ylpropan-1-one;(R)-2-Hydroxy-1-(pyrrolidin-1-yl)propan-1-one;(2R)-2-HYDROXY-1-(PYRROLIDIN-1-YL)PROPAN-1-ONE;SCHEMBL1417346;KLCGBSXTJWOEJD-ZCFIWIBFSA-N;EN300-6478995;(2R)-2-Hydroxy-1-(pyrrolidine-1-yl)propane-1-one

Chemical Property of (2R)-1-oxo-1-pyrrolidinylpropane-2-ol

Chemical Property:

• PSA: 40.54000
• LogP: -0.07250
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 143.094628657
• Heavy Atom Count: 10
• Complexity: 130

Purity/Quality:

(2R)-1-Oxo-1-pyrrolidinylpropane-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)N1CCCC1)O
• Isomeric SMILES: C[C@H](C(=O)N1CCCC1)O

Technology Process of (2R)-1-oxo-1-pyrrolidinylpropane-2-ol

There total 2 articles about (2R)-1-oxo-1-pyrrolidinylpropane-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.99%

pyrrolidine (123-75-1) + (R)-Methyl lactate (17392-83-5,2155-30-8) → (D)-1-(1-pyrrolidinyl)-2-hydroxy-1-propanone (151670-13-2)

Guidance literature:

at 45 ℃; for 13h; Inert atmosphere; Large scale;

Reference yield:

pyrrolidine (123-75-1) + Isobutyl (R)-lactate (61597-96-4,73523-02-1) → (D)-1-(1-pyrrolidinyl)-2-hydroxy-1-propanone (151670-13-2)

Guidance literature:

at 20 ℃; for 96h;

DOI:10.1055/s-2000-7611

Reference yield: 86.0%

(D)-1-(1-pyrrolidinyl)-2-hydroxy-1-propanone (151670-13-2) → (1R)-1-methyl-2-oxo-2-tetrahydro-1H-pyrrolylethyl 2-bromo-2-(2-chlorophenyl)acetate (1198409-05-0)

Guidance literature:

With phosphorus tribromide; at 50 ℃; for 1h;

With bromine; at 50 ℃;

(D)-1-(1-pyrrolidinyl)-2-hydroxy-1-propanone;

upstream raw materials:

pyrrolidine

Isobutyl (R)-lactate

(R)-Methyl lactate

Downstream raw materials:

(1'R)-[2-(4-benzyloxybenzyloxy)-5-bromophenyl]acetic acid 1'-methyl-2'-oxo-2'-pyrrolidin-1'-ylethyl ester

(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (4-isopropylphenyl)(oxo)acetate

Bromo-(4-chloro-phenyl)-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester

(1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl bromo(4-isopropylphenyl)acetate