151670-13-2

Basic information

• Product Name: Pyrrolidine, 1-[(2R)-2-hydroxy-1-oxopropyl]- (9CI)
• Synonyms: Pyrrolidine, 1-[(2R)-2-hydroxy-1-oxopropyl]- (9CI)
• CAS NO: 151670-13-2
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18362
• Product Categories: ACETYLGROUP
• Mol File: 151670-13-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrrolidine, 1-[(2R)-2-hydroxy-1-oxopropyl]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-[(2R)-2-hydroxy-1-oxopropyl]- (9CI)(151670-13-2)
• EPA Substance Registry System: Pyrrolidine, 1-[(2R)-2-hydroxy-1-oxopropyl]- (9CI)(151670-13-2)

Safety Data

• Hazardous Substances Data: 151670-13-2(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 17392-83-5 (R)-Methyl lactate 
• 61597-96-4 Isobutyl (R)-lactate 

Downstream Products

• 1198409-09-4 (1R)-1-methyl-2-oxo-2-tetrahydro-1H-pyrrolylethyl 2-chloro-2-(2-chlorophenyl)acetate 
• 1198409-05-0 (1R)-1-methyl-2-oxo-2-tetrahydro-1H-pyrrolylethyl 2-bromo-2-(2-chlorophenyl)acetate 
• 1449590-18-4 C₂₉H₃₁NO₅ 
• 566202-73-1 [2-(4-Benzyloxy-benzyloxy)-5-bromo-phenyl]-diazo-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester 
• 449779-55-9 Bromo-phenyl-acetic acid (R)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl ester 
• 860780-52-5 (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)[(3-ethyl-2-oxo-5,7-dipropyl-2,3-dihydro-1,3-benzoxazol-6-yl)oxy]acetate 
• 860780-53-6 (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)[(2-methyl-3-oxo-5,7-dipropyl-2,3-dihydro-1,2-benzisoxazol-6-yl)oxy]acetate 
• 860780-51-4 (1R)-1-methyl-2-oxo-2-pyrrolidin-1-ylethyl (2S)-(4-isopropylphenyl)(4-propionyl-2,6-dipropylphenoxy)acetate 

Relevant articles and documents

Synthetic method for antifungal drug intermediate (2R,3S)-1-(1,2,4-triazol)-2-difluorophenyl-2,3-epoxybutane

The invention discloses a synthetic method for an antifungal drug intermediate (2R,3S)-1-(1,2,4-triazol)-2-difluorophenyl-2,3-epoxybutane. The synthetic method comprises the following steps: (1) reacting a compound IV with a Grignard reagent to obtain a compound III; (2) employing a one-pot reaction to react the compound III with trimethylsulfoxonium iodide and 1,2,4-triazole and then react with p-toluenesulfonic acid, so as to obtain a compound II; and (3) reacting the compound II with methanesulfonyl chloride under an alkali condition to generate the target compound I, wherein the Grignard reagent is 2,4-difluorophenylmagnesium bromide or 2,5-difluorophenylmagnesium bromide, and the structural formula of the compound IV is shown in the specification. According to the synthetic route, the reaction conditions are mild and easy to control, the reaction route is simple, the related solvents in the reaction process all are common solvents, the reaction conversion rate is high, and the method possesses extremely high feasibility, is beneficial for industrialized batch production, and possesses extremely large exploitation potential and extremely good application prospect.

Design and synthesis of α-aryloxyphenylacetic acid derivatives: A novel class of PPARα/γ dual agonists with potent antihyperglycemic and lipid modulating activity

The synthesis and structure-activity relationships of novel series of α-aryloxyphenylacetic acids as PPARα/γ dual agonists are reported. The initial search for surrogates of the ester group in the screen lead led first to the optimization of a subseries w