4,6-bis(1-methylhydrazino)-2-(3,4,5-trimethoxyphenyl)pyrimidine

Base Information

• Chemical Name: 4,6-bis(1-methylhydrazino)-2-(3,4,5-trimethoxyphenyl)pyrimidine
• CAS No.: 618428-27-6
• Molecular Formula: C₁₅H₂₂N₆O₃
• Molecular Weight: 334.378
• Mol file: 618428-27-6.mol

Synonyms:4,6-bis(1-methylhydrazino)-2-(3,4,5-trimethoxyphenyl)pyrimidine

Chemical Property of 4,6-bis(1-methylhydrazino)-2-(3,4,5-trimethoxyphenyl)pyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6-bis(1-methylhydrazino)-2-(3,4,5-trimethoxyphenyl)pyrimidine

There total 5 articles about 4,6-bis(1-methylhydrazino)-2-(3,4,5-trimethoxyphenyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methylhydrazine (60-34-4) + 4,6-dichloro-2-(3,4,5-trimethoxyphenyl)pyrimidine (83217-37-2) → 4,6-bis(1-methylhydrazino)-2-(3,4,5-trimethoxyphenyl)pyrimidine (618428-27-6)

Guidance literature:

In ethanol; for 48h; Heating;

DOI:10.1002/hlca.200390137

Reference yield:

2-(3,4,5-trimethoxyphenyl)pyrimidine-4,6-diol (4156-73-4) → 4,6-bis(1-methylhydrazino)-2-(3,4,5-trimethoxyphenyl)pyrimidine (618428-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / POCl₃ / 5 h / Heating

2: 70 percent / ethanol / 48 h / Heating

With trichlorophosphate; In ethanol;

DOI:10.1002/hlca.200390137

Reference yield:

3,4,5-trimethoxybenzenecarboximidamide hydrochloride (4156-59-6) → 4,6-bis(1-methylhydrazino)-2-(3,4,5-trimethoxyphenyl)pyrimidine (618428-27-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 41.6 percent / MeONa / methanol / 24 h / Heating

2: 82 percent / POCl₃ / 5 h / Heating

3: 70 percent / ethanol / 48 h / Heating

With sodium methylate; trichlorophosphate; In methanol; ethanol;

DOI:10.1002/hlca.200390137

upstream raw materials:

methylhydrazine

4,6-dichloro-2-(3,4,5-trimethoxyphenyl)pyrimidine

2-(3,4,5-trimethoxyphenyl)pyrimidine-4,6-diol

3,4,5-trimethoxybenzenecarboximidamide hydrochloride

Downstream raw materials:

pyridine-2-carboxaldehyde methyl[6-(1-methylhydrazino)-2-(3,4,5-trimethoxyphenyl)pyrimidin-4-yl]hydrazone

4,6-bis(1-methylhydrazinyl)-2-phenyl-1-pyrimidine

pyridine-2-carboxaldehyde methyl[6-(1-methylhydrazino)-2-phenylpyrimidin-4-yl]hydrazone

[Zn₄(C₅H₄NCHNN(CH₃)C₄HN₂(C₆H₅)N(CH₃)NCHC₅H₄N)4]⁽⁸⁺⁾