(R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid

Base Information

Chemical Name:(R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid
CAS No.:1354339-88-0
Molecular Formula:C₁₄H₁₅F₃N₂O₃
Molecular Weight:316.28
Hs Code.:

Synonyms:(R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid

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Chemical Property of (R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid

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Technology Process of (R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid

There total 1 articles about (R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 2280-48-0,5174-30-1
(R)-(-)-β-hydroxyvaline

: 1182367-75-4
4-fluoro-3-methyl-2-(trifluoromethyl)benzonitrile

: 1354339-88-0
(R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid

Guidance literature:: (R)-(-)-β-hydroxyvaline; 4-fluoro-3-methyl-2-(trifluoromethyl)benzonitrile; With potassium carbonate; In dimethyl sulfoxide; at 85 ℃; for 18h;

With citric acid; In water;

Reference yield: 99.0%

: 43038-36-4
4-cyanobenzohydrazide

: 1354339-88-0
(R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid

: 1354339-95-9
(R)-4-cyano-N'-(2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoyl)benzohydrazide

Guidance literature:: 4-cyanobenzohydrazide; (R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid; In tetrahydrofuran; at -15 ℃; Inert atmosphere;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at -20 - 20 ℃;

Reference yield: 92.0%

: 456-06-4
4-fluorobenzoyl hydrazide

: 1354339-88-0
(R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid

: 1354339-89-1
(R)-N'-(2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoyl)-4-fluorobenzohydrazide

Guidance literature:: 4-fluorobenzoyl hydrazide; (R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid; In tetrahydrofuran; at -15 ℃; Inert atmosphere;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at -20 - 20 ℃;