(R)-N'-(2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoyl)-4-fluorobenzohydrazide

Base Information

Chemical Name:(R)-N'-(2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoyl)-4-fluorobenzohydrazide
CAS No.:1354339-89-1
Molecular Formula:C₂₁H₂₀F₄N₄O₃
Molecular Weight:452.408
Hs Code.:

Synonyms:(R)-N'-(2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoyl)-4-fluorobenzohydrazide

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Chemical Property of (R)-N'-(2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoyl)-4-fluorobenzohydrazide

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Technology Process of (R)-N'-(2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoyl)-4-fluorobenzohydrazide

There total 3 articles about (R)-N'-(2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoyl)-4-fluorobenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 456-06-4
4-fluorobenzoyl hydrazide

: 1354339-88-0
(R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid

: 1354339-89-1
(R)-N'-(2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoyl)-4-fluorobenzohydrazide

Guidance literature:: 4-fluorobenzoyl hydrazide; (R)-2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoic acid; In tetrahydrofuran; at -15 ℃; Inert atmosphere;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at -20 - 20 ℃;

Reference yield:

: 1182367-75-4
4-fluoro-3-methyl-2-(trifluoromethyl)benzonitrile

: 1354339-89-1
(R)-N'-(2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoyl)-4-fluorobenzohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 18 h / 85 °C

2.1: tetrahydrofuran / -15 °C / Inert atmosphere

2.2: -20 - 20 °C

With potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 2280-48-0,5174-30-1
(R)-(-)-β-hydroxyvaline

: 1354339-89-1
(R)-N'-(2-(4-cyano-2-methyl-3-(trifluoromethyl)phenylamino)-3-hydroxy-3-methylbutanoyl)-4-fluorobenzohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 18 h / 85 °C

2.1: tetrahydrofuran / -15 °C / Inert atmosphere

2.2: -20 - 20 °C

With potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide;