2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 88875-62-1
• Molecular Formula: C₂₃H₁₆Cl₄O₄
• Molecular Weight: 498.19
• Mol file: 88875-62-1.mol

Synonyms:2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester

Chemical Property of 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester

There total 6 articles about 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

α-(4-chlorophenyl)phenylacetic acid (21771-88-0) + 2,2,2-trichloroethyl salicylate (56529-85-2) → 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester (88875-62-1)

Guidance literature:

With methanesulfonyl chloride; In pyridine; toluene; for 10h; Ambient temperature;

DOI:10.1248/cpb.31.2632

Reference yield:

2-bromo-2-(4-chlorophenyl)acetonitrile (53731-99-0) → 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester (88875-62-1)

Guidance literature:

Multi-step reaction with 3 steps

1: AlCl₃ / 3 h / Heating

2: 90 percent / H₂SO₄ / H₂O / 8 h / Heating

3: 83 percent / CH₃SO₂Cl / toluene; pyridine / 10 h / Ambient temperature

With aluminium trichloride; sulfuric acid; methanesulfonyl chloride; In pyridine; water; toluene;

DOI:10.1248/cpb.31.2632

Reference yield:

salicylic acid (69-72-7,25496-36-0,8052-31-1) → 2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid 2,2,2-trichloro-ethyl ester (88875-62-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / DCC, DMAP / tetrahydrofuran / Ambient temperature

2: 83 percent / CH₃SO₂Cl / toluene; pyridine / 10 h / Ambient temperature

With dmap; methanesulfonyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; pyridine; toluene;

DOI:10.1248/cpb.31.2632

upstream raw materials:

α-(4-chlorophenyl)phenylacetic acid

2,2,2-trichloroethyl salicylate

2-bromo-2-(4-chlorophenyl)acetonitrile

salicylic acid

Downstream raw materials:

2-[2-(4-Chloro-phenyl)-2-phenyl-acetoxy]-benzoic acid