(2E,4S)-4-hydroxy-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-enyl 2,2-dimethylpropanoate

Base Information

• Chemical Name: (2E,4S)-4-hydroxy-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-enyl 2,2-dimethylpropanoate
• CAS No.: 157918-45-1
• Molecular Formula: C₃₁H₃₆O₅
• Molecular Weight: 488.624
• Mol file: 157918-45-1.mol

Synonyms:(2E,4S)-4-hydroxy-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-enyl 2,2-dimethylpropanoate

Chemical Property of (2E,4S)-4-hydroxy-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-enyl 2,2-dimethylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4S)-4-hydroxy-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-enyl 2,2-dimethylpropanoate

There total 6 articles about (2E,4S)-4-hydroxy-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-enyl 2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(2E,4S)-4-<<(tert-butyl)dimethyl>silyloxy>-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-enyl 2,2-dimethylpropanoate (157918-43-9) → (2E,4S)-4-hydroxy-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-enyl 2,2-dimethylpropanoate (157918-45-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1002/hlca.19940770323

Reference yield:

pivaloyl chloride (3282-30-2) → (2E,4S)-4-hydroxy-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-enyl 2,2-dimethylpropanoate (157918-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / pyridine / Ambient temperature

2: 51 percent / Bu₄NF*3H₂O / tetrahydrofuran / 24 h / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1002/hlca.19940770323

Reference yield:

methyl (2E,4S)-4-<<(tert-butyl)dimethylsilyl>oxy>-6-hydroxyhex-2-eneoate (109462-36-4) → (2E,4S)-4-hydroxy-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-enyl 2,2-dimethylpropanoate (157918-45-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / pyridine / 24 h / Ambient temperature

2: 90 percent / DIBAL / hexane / 1 h / -70 °C

3: 85 percent / pyridine / Ambient temperature

4: 51 percent / Bu₄NF*3H₂O / tetrahydrofuran / 24 h / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; In tetrahydrofuran; hexane;

DOI:10.1002/hlca.19940770323

upstream raw materials:

(2E,4S)-4-<<(tert-butyl)dimethyl>silyloxy>-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-enyl 2,2-dimethylpropanoate

pivaloyl chloride

methyl (2E,4S)-4-<<(tert-butyl)dimethylsilyl>oxy>-6-hydroxyhex-2-eneoate

(2E,4S)-4-<<(tert-butyl)dimethylsilyl>oxy>-6-<(4-methoxyphenyl)(diphenyl)methoxy>hex-2-en-1-ol