(5S)-1-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline

Base Information

Chemical Name:(5S)-1-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline
CAS No.:134816-20-9
Molecular Formula:C₂₃H₃₅NO₄Si
Molecular Weight:417.621
Hs Code.:

Synonyms:(5S)-1-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline

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Chemical Property of (5S)-1-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline

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Technology Process of (5S)-1-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline

There total 20 articles about (5S)-1-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 67-56-1
methanol

: 142350-56-9
(S)-5-Benzyl-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyryl]-4-hydroxy-1,5-dihydro-pyrrol-2-one

: 134816-20-9
(5S)-1-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline

: 134816-20-9,142350-61-6
(5S)-1-<(2R)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4020(01)92190-8

Reference yield: 60.0%

: 67-56-1
methanol

: 142350-56-9
(S)-5-Benzyl-1-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyryl]-4-hydroxy-1,5-dihydro-pyrrol-2-one

: 134816-20-9
(5S)-1-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline

: 134816-20-9,142350-61-6
(5S)-1-<(2R)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4020(01)92190-8

Reference yield: 46.0%

: 67-56-1
methanol

: 134816-27-6
N-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-L-phenylalanine

: 134816-20-9
(5S)-1-<(2S)-O-tert-butyldimethylsilyl-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline

: t-butyldimethylsilyl-(S)-Hiva-(R)-Dpy

Guidance literature:: With dmap; cycl-isopropylidene malonate; 2-chloro-1,3-dimethyl-2-imidazolinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; Yield given; Multistep reaction; 1.) THF, 25 deg C, 4 h, 2.) AcOEt, reflux, 1 h, 3.) THF, 25 deg C, 2 h;
DOI:10.1021/jo981055a