1-(4-(2-(trifluoromethyl)phenyl)pyridin-1(4H)-yl)ethanone

Base Information

• Chemical Name: 1-(4-(2-(trifluoromethyl)phenyl)pyridin-1(4H)-yl)ethanone
• CAS No.: 1422252-47-8
• Molecular Formula: C₁₄H₁₂F₃NO
• Molecular Weight: 267.251
• Mol file: 1422252-47-8.mol

Synonyms:1-(4-(2-(trifluoromethyl)phenyl)pyridin-1(4H)-yl)ethanone

Chemical Property of 1-(4-(2-(trifluoromethyl)phenyl)pyridin-1(4H)-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(4-(2-(trifluoromethyl)phenyl)pyridin-1(4H)-yl)ethanone

There total 1 articles about 1-(4-(2-(trifluoromethyl)phenyl)pyridin-1(4H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

pyridine (110-86-1) + o-trifluoromethylphenyl bromide (392-83-6) + acetyl chloride (75-36-5) → 1-(4-(2-(trifluoromethyl)phenyl)pyridin-1(4H)-yl)ethanone (1422252-47-8) + C14H12F3NO

Guidance literature:

o-trifluoromethylphenyl bromide; With isopropylmagnesium bromide; In tetrahydrofuran; at 20 - 30 ℃; Large scale;

pyridine; With copper(l) iodide; In tetrahydrofuran; at 20 - 25 ℃; for 0.333333h; Large scale;

acetyl chloride; at -5 - 25 ℃; for 3.33333h; regioselective reaction; Large scale;

DOI:10.1021/op300331b

Reference yield:

1-(4-(2-(trifluoromethyl)phenyl)pyridin-1(4H)-yl)ethanone (1422252-47-8) → 1-(4-(2-(trifluoromethyl)phenyl)piperidin-1-yl)ethanone (1422252-48-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 50 - 55 ℃; for 12h; under 10343.2 Torr; Inert atmosphere; Large scale;

DOI:10.1021/op300331b

Reference yield:

1-(4-(2-(trifluoromethyl)phenyl)pyridin-1(4H)-yl)ethanone (1422252-47-8) → 4-(1-acetylpiperidin-4-yl)-3-(trifluoromethyl)methylbenzoate (1204331-63-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 50 - 55 °C / 10343.2 Torr / Inert atmosphere; Large scale

2.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; acetic acid / methanol; dichloromethane / Large scale

3.1: triethylamine / methanol / 258.58 Torr / Inert atmosphere; Large scale

3.2: 20 h / 90 - 92 °C / 5171.62 Torr / Inert atmosphere; Large scale

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; In methanol; dichloromethane;

DOI:10.1021/op300331b

upstream raw materials:

pyridine

o-trifluoromethylphenyl bromide

acetyl chloride

Downstream raw materials:

1-(4-(2-(trifluoromethyl)phenyl)piperidin-1-yl)ethanone

1-(4-(4-bromo-2-(trifluoromethyl)phenyl)piperidin-1-yl)ethanone

C₁₄H₁₅BrF₃NO

C₁₄H₁₄Br₂F₃NO