(R)-methyl 2-(2-(2-(2-(pyrrolidine-2-carboxamido)benzamido)benzamido)benzamido)benzoate

Base Information

• Chemical Name: (R)-methyl 2-(2-(2-(2-(pyrrolidine-2-carboxamido)benzamido)benzamido)benzamido)benzoate
• CAS No.: 1448441-20-0
• Molecular Formula: C₃₄H₃₁N₅O₆
• Molecular Weight: 605.65
• Mol file: 1448441-20-0.mol

Synonyms:(R)-methyl 2-(2-(2-(2-(pyrrolidine-2-carboxamido)benzamido)benzamido)benzamido)benzoate

Chemical Property of (R)-methyl 2-(2-(2-(2-(pyrrolidine-2-carboxamido)benzamido)benzamido)benzamido)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-methyl 2-(2-(2-(2-(pyrrolidine-2-carboxamido)benzamido)benzamido)benzamido)benzoate

There total 9 articles about (R)-methyl 2-(2-(2-(2-(pyrrolidine-2-carboxamido)benzamido)benzamido)benzamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-tert-butyl 2-{[2-({2-[(2-{[2-(methoxycarbonyl)phenyl]carbamoyl}phenyl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}pyrrolidine-1-carboxylate (1448441-23-3) → (R)-methyl 2-(2-(2-(2-(pyrrolidine-2-carboxamido)benzamido)benzamido)benzamido)benzoate (1448441-20-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/ja405455g

Reference yield:

2-nitrobenzyl chloride (610-14-0) → (R)-methyl 2-(2-(2-(2-(pyrrolidine-2-carboxamido)benzamido)benzamido)benzamido)benzoate (1448441-20-0)

Guidance literature:

Multi-step reaction with 8 steps

1: triethylamine / dichloromethane

2: palladium(II) hydroxide; methanol / 4 h

3: triethylamine / dichloromethane

4: palladium(II) hydroxide; methanol / 4 h

5: triethylamine / dichloromethane

6: palladium(II) hydroxide; methanol / 4 h

7: tetrahydrofuran / 0 - 70 °C

8: trifluoroacetic acid / dichloromethane / 20 °C

With methanol; palladium(II) hydroxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja405455g

Reference yield:

methyl N-<2-(o-aminobenzamido)benzoyl>anthranilate (77149-26-9) → (R)-methyl 2-(2-(2-(2-(pyrrolidine-2-carboxamido)benzamido)benzamido)benzamido)benzoate (1448441-20-0)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane

2: palladium(II) hydroxide; methanol / 4 h

3: tetrahydrofuran / 0 - 70 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

With methanol; palladium(II) hydroxide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja405455g

upstream raw materials:

2-nitrobenzyl chloride

methyl N-<2-(o-aminobenzamido)benzoyl>anthranilate

(R)-tert-butyl 2-{[2-({2-[(2-{[2-(methoxycarbonyl)phenyl]carbamoyl}phenyl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}pyrrolidine-1-carboxylate

2-carbomethoxyaniline

Downstream raw materials:

methyl 2-(2-(2-(2-((R)-1-(2-(2-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzamido)benzamido)benzoyl)pyrrolidine-2-carboxamido)benzamido)benzamido)benzamido)benzoate