77149-26-9Relevant academic research and scientific papers
A synthetic zipper peptide motif orchestrated via co-operative interplay of hydrogen bonding, aromatic stacking, and backbone chirality
Nair, Roshna V.,Kheria, Sanjeev,Rayavarapu, Suresh,Kotmale, Amol S.,Jagadeesh, Bharatam,Gonnade, Rajesh G.,Puranik, Vedavati G.,Rajamohanan, Pattuparambil R.,Sanjayan, Gangadhar J.
supporting information, p. 11477 - 11480 (2013/09/02)
Here, we report on a new class of synthetic zipper peptide which assumes its three-dimensional zipper-like structure via a co-operative interplay of hydrogen bonding, aromatic stacking, and backbone chirality. Structural studies carried out in both solid- and solution-state confirmed the zipper-like structural architecture assumed by the synthetic peptide which makes use of unusually remote inter-residual hydrogen-bonding and aromatic stacking interactions to attain its shape. The effect of chirality modulation and the extent of noncovalent forces in the structure stabilization have also been comprehensively explored via single-crystal X-ray diffraction and solution-state NMR studies. The results highlight the utility of noncovalent forces in engineering complex synthetic molecules with intriguing structural architectures.
One dimensional unichemo protection (UCP) in organic synthesis
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, (2015/04/15)
A protected template molecule and a new one-dimensional UniChemo Protection (UCP) organic synthetic method for preparing polyfunctional organic molecules is described. The synthetic method can be used with many kinds of chemical reactions and provides selective access to many functional groups in a template molecule. The method utilizes protection groups that are each composed of building block units that can be removed one by one affording a new protection group one unit shorter or exposing a functional group on the template molecule. The exposed functional group on the template molecule can react with a target group. Different target groups can be introduced into the template molecule by using protection groups containing different numbers of building block units.
Oligoanthranilamides. Non-peptide subunits that show formation of specific secondary structure
Hamuro, Yoshitomo,Geib, Steven J.,Hamilton, Andrew D.
, p. 7529 - 7541 (2007/10/03)
A family of novel oligomers based on the anthranilamide nucleus has been prepared and shown to form well-defined secondary structural features. 1H NMR and X-ray crystallographic techniques have demonstrated that intramolecular hydrogen bonds play a key role in stabilizing both linear sheet and helical conformational forms.
Conformational Behaviour of Medium-sized Rings. Part 14. Tetraanthranilides
Hoorfar, Alireza,Ollis, W. David,Stoddart, J. Fraser
, p. 1721 - 1726 (2007/10/02)
The stepwise synthesis of N,N',N''-trimethyltetra-anthranilide (13) is reported and the temperature dependence of the 1H n.m.r. spectrum of N-benzyl-N',N'',N'''-trimethyltetra-anthranilide (15) is interpreted in terms of equilibration between three diaste
SYNTHESIS AND CONFORMATIONAL BEHAVIOUR OF TETRA-ANTHRANILIDES
Hoorfar, Alireza,Ollis, Dawid W.,Stoddart, Fraser J.,Williams, David J.
, p. 4211 - 4214 (2007/10/02)
The tetra-anthranilide derivatives (5)-(7) have been synthesised.X-ray crystallography shows that N,N,,N,,-trimethyltetra-anthanilide (5) adopts a conformation with three trans- and one cis-amide linkages in the solid state.Dynamic
