3-ethyl-6-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-phenyl-1Hindazole hydrochloride

Base Information

Chemical Name:3-ethyl-6-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-phenyl-1Hindazole hydrochloride
CAS No.:1345404-57-0
Molecular Formula:C₂₁H₂₄N₄*ClH
Molecular Weight:368.909
Hs Code.:

Synonyms:3-ethyl-6-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-phenyl-1Hindazole hydrochloride

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Chemical Property of 3-ethyl-6-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-phenyl-1Hindazole hydrochloride

Chemical Property:

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Technology Process of 3-ethyl-6-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-phenyl-1Hindazole hydrochloride

There total 5 articles about 3-ethyl-6-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-phenyl-1Hindazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₂N₄O₂

: 1345404-57-0
3-ethyl-6-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-phenyl-1Hindazole hydrochloride

Guidance literature:: With hydrogenchloride; methanol; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2011.06.067

Reference yield:

: 1332527-10-2
1-(1-(4-bromo-2-fluorophenyl)propylidene)-2-phenylhydrazine

: 1345404-57-0
3-ethyl-6-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-phenyl-1Hindazole hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 100 °C

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Reflux; Inert atmosphere

3: hydrogenchloride; methanol / 2 h / 20 °C

With hydrogenchloride; methanol; palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In N,N-dimethyl-formamide; toluene; 2: Buchwald amination;
DOI:10.1016/j.bmcl.2011.06.067

Reference yield:

: 100-63-0
phenylhydrazine

: 1345404-57-0
3-ethyl-6-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1-phenyl-1Hindazole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / water / 1 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 48 h / 100 °C

3: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Reflux; Inert atmosphere

4: hydrogenchloride; methanol / 2 h / 20 °C

With hydrogenchloride; methanol; palladium diacetate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In water; N,N-dimethyl-formamide; toluene; 3: Buchwald amination;
DOI:10.1016/j.bmcl.2011.06.067