N-(4-Fluoro-3-chloro-phenyl)-2-[N-methyl-N-(2,2-difluoroethyl)-amino]-4-methylamino-5-amino-benzoic acid amide

Base Information

Chemical Name:N-(4-Fluoro-3-chloro-phenyl)-2-[N-methyl-N-(2,2-difluoroethyl)-amino]-4-methylamino-5-amino-benzoic acid amide
CAS No.:1380836-02-1
Molecular Formula:C₁₇H₁₈ClF₃N₄O
Molecular Weight:386.804
Hs Code.:

Synonyms:N-(4-Fluoro-3-chloro-phenyl)-2-[N-methyl-N-(2,2-difluoroethyl)-amino]-4-methylamino-5-amino-benzoic acid amide

Suppliers and Price of N-(4-Fluoro-3-chloro-phenyl)-2-[N-methyl-N-(2,2-difluoroethyl)-amino]-4-methylamino-5-amino-benzoic acid amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(4-Fluoro-3-chloro-phenyl)-2-[N-methyl-N-(2,2-difluoroethyl)-amino]-4-methylamino-5-amino-benzoic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-Fluoro-3-chloro-phenyl)-2-[N-methyl-N-(2,2-difluoroethyl)-amino]-4-methylamino-5-amino-benzoic acid amide

There total 4 articles about N-(4-Fluoro-3-chloro-phenyl)-2-[N-methyl-N-(2,2-difluoroethyl)-amino]-4-methylamino-5-amino-benzoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380840-76-5
N-(4-fluoro-3-chloro-phenyl)-2-[N-methyl-N-(2,2-difluoroethyl)-amino]-4-methylamino-5-nitro-benzoic acid amide

: 1380836-02-1
N-(4-Fluoro-3-chloro-phenyl)-2-[N-methyl-N-(2,2-difluoroethyl)-amino]-4-methylamino-5-amino-benzoic acid amide

Guidance literature:: With hydrogen; Ra-Ni; In tetrahydrofuran; for 4h; under 2585.81 Torr;

Reference yield:

: 153775-33-8
2,4-difluoro-5-nitro-benzoic acid

: 1380836-02-1
N-(4-Fluoro-3-chloro-phenyl)-2-[N-methyl-N-(2,2-difluoroethyl)-amino]-4-methylamino-5-amino-benzoic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water / 0.5 h / 20 °C / Cooling with ice

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h

2.2: 2 h

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 336 h

4.1: hydrogen / Ra-Ni / tetrahydrofuran / 4 h / 2585.81 Torr

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; hydrogen; N-ethyl-N,N-diisopropylamine; Ra-Ni; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 1242270-10-5
2-fluoro-4-methylamino-5-nitro-benzoic acid

: 1380836-02-1
N-(4-Fluoro-3-chloro-phenyl)-2-[N-methyl-N-(2,2-difluoroethyl)-amino]-4-methylamino-5-amino-benzoic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h

1.2: 2 h

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 336 h

3.1: hydrogen / Ra-Ni / tetrahydrofuran / 4 h / 2585.81 Torr

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; hydrogen; N-ethyl-N,N-diisopropylamine; Ra-Ni; In tetrahydrofuran; dichloromethane; acetonitrile;