5-amino-2-bromo-3-fluorobenzoate methyl ester

Base Information Edit

Chemical Name:5-amino-2-bromo-3-fluorobenzoate methyl ester
CAS No.:1036389-05-5
Molecular Formula:C₈H₇BrFNO₂
Molecular Weight:248.051
Hs Code.:
Mol file:1036389-05-5.mol

Synonyms:5-amino-2-bromo-3-fluorobenzoate methyl ester

Suppliers and Price of 5-amino-2-bromo-3-fluorobenzoate methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 5-amino-2-bromo-3-fluorobenzoate methyl ester Edit

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 5-amino-2-bromo-3-fluorobenzoate methyl ester

There total 7 articles about 5-amino-2-bromo-3-fluorobenzoate methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 67-56-1
methanol

: 132715-69-6
2-bromo-3-fluoro-benzoic acid

: 1036389-05-5
5-amino-2-bromo-3-fluorobenzoate methyl ester

: 1036390-96-1
6-amino-2-bromo-3-fluorobenzoate methyl ester

Guidance literature:: 2-bromo-3-fluoro-benzoic acid; With sulfuric acid; nitric acid; In water; at 20 ℃; for 2h;

With thionyl chloride; for 1h; Reflux;

methanol; Further stages;

Reference yield:

: 67-56-1
methanol

: 881415-28-7
2-bromo-3-fluoro-5-nitrobenzoic acid

: 881415-27-6
2-bromo-3-fluoro-6-nitrobenzoic acid

: 1036389-05-5
5-amino-2-bromo-3-fluorobenzoate methyl ester

: 1036390-96-1
6-amino-2-bromo-3-fluorobenzoate methyl ester

Guidance literature:: 2-bromo-3-fluoro-5-nitrobenzoic acid; 2-bromo-3-fluoro-6-nitrobenzoic acid; With thionyl chloride; for 1h; Heating / reflux;

methanol; for 1h; Heating / reflux;

With iron; acetic acid; at 90 ℃; for 4h;

Reference yield:

: 881415-28-7
2-bromo-3-fluoro-5-nitrobenzoic acid

: 1036389-05-5
5-amino-2-bromo-3-fluorobenzoate methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 0.5 h / 0 °C / Inert atmosphere

1.2: 18 h / 60 °C / Inert atmosphere

2.1: iron; acetic acid / water; ethanol / 1 h / 110 °C

With thionyl chloride; iron; acetic acid; In ethanol; water;
DOI:10.1021/acsmedchemlett.6b00282