(7S,10S,13S)-13-(4-fluoro-benzenesulfonylamino)-10-isobutyl-9,12-dioxo-2-oxa-8,11-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-triene-7-carboxylic acid methyl ester

Base Information

• Chemical Name: (7S,10S,13S)-13-(4-fluoro-benzenesulfonylamino)-10-isobutyl-9,12-dioxo-2-oxa-8,11-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-triene-7-carboxylic acid methyl ester
• CAS No.: 1020257-30-0
• Molecular Formula: C₂₈H₃₆FN₃O₇S
• Molecular Weight: 577.674

Synonyms:(7S,10S,13S)-13-(4-fluoro-benzenesulfonylamino)-10-isobutyl-9,12-dioxo-2-oxa-8,11-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-triene-7-carboxylic acid methyl ester

Chemical Property of (7S,10S,13S)-13-(4-fluoro-benzenesulfonylamino)-10-isobutyl-9,12-dioxo-2-oxa-8,11-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-triene-7-carboxylic acid methyl ester

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Technology Process of (7S,10S,13S)-13-(4-fluoro-benzenesulfonylamino)-10-isobutyl-9,12-dioxo-2-oxa-8,11-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-triene-7-carboxylic acid methyl ester

There total 13 articles about (7S,10S,13S)-13-(4-fluoro-benzenesulfonylamino)-10-isobutyl-9,12-dioxo-2-oxa-8,11-diaza-bicyclo[13.2.2]nonadeca-1⁽¹⁸⁾,15⁽¹⁹⁾,16-triene-7-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(7S,10S,13S)-13-(4-fluoro-benzenesulfonylamino)-10-isobutyl-9,12-dioxo-2-oxa-8,11-diaza-bicyclo[13.2.2]nonadeca-1(18),4,15(19),16-tetraene-7-carboxylic acid methyl ester → (7S,10S,13S)-13-(4-fluoro-benzenesulfonylamino)-10-isobutyl-9,12-dioxo-2-oxa-8,11-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-triene-7-carboxylic acid methyl ester (1020257-30-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; dichloromethane; ethyl acetate; at 20 ℃; for 18h; under 760.051 Torr;

Reference yield: 7.0%

C22H33N3O5 + 4-Fluorobenzenesulfonyl chloride (349-88-2) → (7S,10S,13S)-13-(4-fluoro-benzenesulfonylamino)-10-isobutyl-9,12-dioxo-2-oxa-8,11-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-triene-7-carboxylic acid methyl ester (1020257-30-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1071/CH14121

Reference yield:

C28H38FN3O8S → (7S,10S,13S)-13-(4-fluoro-benzenesulfonylamino)-10-isobutyl-9,12-dioxo-2-oxa-8,11-diaza-bicyclo[13.2.2]nonadeca-1(18),15(19),16-triene-7-carboxylic acid methyl ester (1020257-30-0)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1071/CH14121

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

N-(tert-butyloxycarbonyl)-O-allyl-(S)-tyrosine

methyl (L)-leucinate hydrochloride

(S)-2-[(S)-3-(4-allyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid methyl ester

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