(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 2-(5-methoxy-2-nitrophenyl)acrylate

Base Information

Chemical Name:(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 2-(5-methoxy-2-nitrophenyl)acrylate
CAS No.:391277-58-0
Molecular Formula:C₁₆H₁₇NO₇
Molecular Weight:335.313
Hs Code.:

Synonyms:(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 2-(5-methoxy-2-nitrophenyl)acrylate

Suppliers and Price of (3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 2-(5-methoxy-2-nitrophenyl)acrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 2-(5-methoxy-2-nitrophenyl)acrylate

Chemical Property:

Purity/Quality:

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Technology Process of (3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 2-(5-methoxy-2-nitrophenyl)acrylate

There total 7 articles about (3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 2-(5-methoxy-2-nitrophenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 599-04-2
(R)-Pantolacton

: 391277-45-5
2-(5-methoxy-2-nitrophenyl)acrylic acid

: 391277-58-0
(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 2-(5-methoxy-2-nitrophenyl)acrylate

Guidance literature:: With dmap; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In dichloromethane; Heating;
DOI:10.1021/jo015854w

Reference yield:

: 5367-32-8
5-methoxy-2-nitrotoluene

: 391277-58-0
(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 2-(5-methoxy-2-nitrophenyl)acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaOEt / diethyl ether; ethanol / 3 h / 20 °C

1.2: 67 percent / 30percent H₂O₂; 2M NaOH / H₂O / 1 h / 20 °C / pH 9

2.1: 95 percent / Amberlyst-15 / 2 h / Heating

3.1: 76 percent / K₂CO₃; TDA-1 / toluene / 3 h / 85 °C

4.1: 80 percent / aq. NaOH / 1 h / Heating

5.1: 45 percent / DMAP; 1-hydroxybenzotriazole hydrate; DCC / CH₂Cl₂ / Heating

With dmap; sodium hydroxide; amberlyst-15; sodium ethanolate; potassium carbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In diethyl ether; ethanol; dichloromethane; toluene;
DOI:10.1021/jo015854w

Reference yield:

: 20876-29-3
2-(5-methoxy-2-nitrophenyl)acetic acid

: 391277-58-0
(3R)-4,4-dimethyl-2-oxotetrahydrofuran-3-yl 2-(5-methoxy-2-nitrophenyl)acrylate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Amberlyst-15 / 2 h / Heating

2: 76 percent / K₂CO₃; TDA-1 / toluene / 3 h / 85 °C

3: 80 percent / aq. NaOH / 1 h / Heating

4: 45 percent / DMAP; 1-hydroxybenzotriazole hydrate; DCC / CH₂Cl₂ / Heating

With dmap; sodium hydroxide; amberlyst-15; potassium carbonate; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In dichloromethane; toluene;
DOI:10.1021/jo015854w