3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide hydrochloride

Base Information

• Chemical Name: 3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide hydrochloride
• CAS No.: 1236284-40-4
• Molecular Formula: C₂₀H₂₂F₂N₆O*ClH
• Molecular Weight: 436.892

Synonyms:3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide hydrochloride

Chemical Property of 3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide hydrochloride

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Technology Process of 3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide hydrochloride

There total 1 articles about 3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-[4-(4-dimethylcarbamoyl-2-fluorophenylamino)-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate (1236281-72-3) → 3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide hydrochloride (1236284-40-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield: 73.0%

3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide hydrochloride (1236284-40-4) + isopropyl chloroformate (108-23-6) → isopropyl 4-[4-(4-dimethylcarbamoyl-2-fluorophenylamino)-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate (1236281-75-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 64.0%

4-nitrophenyl pentan-3-yl carbonate (1236284-41-5) + 3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide hydrochloride (1236284-40-4) → 1-ethylpropyl 4-[4-(4-dimethylcarbamoyl-2-fluorophenylamino)-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate (1236281-76-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 15h;

upstream raw materials:

tert-butyl 4-[4-(4-dimethylcarbamoyl-2-fluorophenylamino)-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate

Downstream raw materials:

4-[7-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-5-fluoro-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-3-fluoro-N,N-dimethylbenzamide

3-fluoro-4-[5-fluoro-7-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide

isopropyl 4-[4-(4-dimethylcarbamoyl-2-fluorophenylamino)-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl]piperidine-1-carboxylate

3-fluoro-4-[5-fluoro-7-(piperidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]-N,N-dimethylbenzamide

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