(E)-2-nitro-5-(4-(prop-2-yn-1-yloxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

Base Information

Chemical Name:(E)-2-nitro-5-(4-(prop-2-yn-1-yloxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate
CAS No.:1384982-42-6
Molecular Formula:C₃₂H₃₂Cl₂N₂O₅
Molecular Weight:595.522
Hs Code.:

Synonyms:(E)-2-nitro-5-(4-(prop-2-yn-1-yloxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

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Chemical Property of (E)-2-nitro-5-(4-(prop-2-yn-1-yloxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

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Technology Process of (E)-2-nitro-5-(4-(prop-2-yn-1-yloxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

There total 15 articles about (E)-2-nitro-5-(4-(prop-2-yn-1-yloxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.1%

: 1384982-41-5
(E)-5-(4-hydroxystyryl)-2-nitrobenzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

: 106-96-7
propargyl bromide

: 1384982-42-6
(E)-2-nitro-5-(4-(prop-2-yn-1-yloxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 6h; Darkness;
DOI:10.1039/c2ob25701g

Reference yield:

: 1261777-72-3
2-(bromomethyl)-4-iodo-1-nitrobenzene

: 1384982-42-6
(E)-2-nitro-5-(4-(prop-2-yn-1-yloxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: water; sodium carbonate / acetone / 48 h / Reflux

2: palladium diacetate / triethanolamine; N,N-dimethyl-formamide / 12 h / 110 °C / Inert atmosphere

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 12 h / 20 °C / Darkness

4: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Darkness

5: potassium carbonate / acetone / 6 h / 20 °C / Darkness

With dmap; water; palladium diacetate; sodium carbonate; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In triethanolamine; dichloromethane; N,N-dimethyl-formamide; acetone; 2: Heck reaction;
DOI:10.1039/c2ob25701g

Reference yield:

: 1384982-50-6
(E)-2-nitro-5-(4-((tetrahydro-2H-pyran-2-yl)oxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

: 1384982-42-6
(E)-2-nitro-5-(4-(prop-2-yn-1-yloxy)styryl)benzyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C / Darkness

2: potassium carbonate / acetone / 6 h / 20 °C / Darkness

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetone;
DOI:10.1039/c2ob25701g