3-{[(3-amino-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoyl)(cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenyl ethylcarbamate

Base Information

Chemical Name:3-{[(3-amino-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoyl)(cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenyl ethylcarbamate
CAS No.:921629-93-8
Molecular Formula:C₃₆H₄₅Cl₂N₃O₆
Molecular Weight:686.676
Hs Code.:

Synonyms:3-{[(3-amino-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoyl)(cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenyl ethylcarbamate

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Chemical Property of 3-{[(3-amino-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoyl)(cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenyl ethylcarbamate

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Technology Process of 3-{[(3-amino-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoyl)(cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenyl ethylcarbamate

There total 16 articles about 3-{[(3-amino-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoyl)(cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenyl ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(((3-((tert-butoxycarbonyl)amino)-2-(4-(2-(2,6-dichloro-4-methylphenoxy)ethoxy)benzyl)propanoyl)(cyclopropyl)amino)methyl)-5-(3-methoxypropyl)phenyl ethylcarbamate

: 921629-93-8
3-{[(3-amino-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoyl)(cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenyl ethylcarbamate

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1026786-84-4
3-hydroxy-5-[(1E)-3-(methyloxy)-1-propen-1-yl]benzaldehyde

: 921629-93-8
3-{[(3-amino-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoyl)(cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenyl ethylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: magnesium sulfate / dichloromethane / 12 h / 20 °C

2.2: 3 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 20 °C

6.1: dmap; triethylamine / dichloromethane / 1.5 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; tetrabutyl ammonium fluoride; hydrogen; magnesium sulfate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1026786-89-9
[(3-{[(tert-butyl)(dimethyl)silyl]oxy}-5-{(1E)-3-methoxyprop-1-en-1-yl}benzyl)amino]cyclopropane

: 921629-93-8
3-{[(3-amino-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}propanoyl)(cyclopropyl)amino]methyl}-5-(3-methoxypropyl)phenyl ethylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1.5 h

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 20 °C

4: dmap; triethylamine / dichloromethane / 1.5 h / 20 °C

5: hydrogenchloride / 1,4-dioxane; dichloromethane / 3 h / 20 °C

With hydrogenchloride; dmap; tetrabutyl ammonium fluoride; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;