(S)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-3-(2-methyl-propane-2-sulfonyl)-propionamide

Base Information

Chemical Name:(S)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-3-(2-methyl-propane-2-sulfonyl)-propionamide
CAS No.:150545-00-9
Molecular Formula:C₄₃H₅₅N₇O₁₀S
Molecular Weight:862.017
Hs Code.:

(S)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-3-(2-methyl-propane-2-sulfonyl)-propionamide

Synonyms:(S)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-3-(2-methyl-propane-2-sulfonyl)-propionamide

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Chemical Property of (S)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-3-(2-methyl-propane-2-sulfonyl)-propionamide

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Technology Process of (S)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-3-(2-methyl-propane-2-sulfonyl)-propionamide

There total 6 articles about (S)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-3-(2-methyl-propane-2-sulfonyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.1%

: 114530-04-0
(S)-α-[[(1,1-dimethylethyl)-sulfonyl]methyl]benzenepropanoic acid

: 150577-71-2
N-im-(2,4-dinitrophenyl)-L-histidyl>-(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexan-2-amine

: 150545-00-9
(S)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-3-(2-methyl-propane-2-sulfonyl)-propionamide

Guidance literature:: With N-ethylmorpholine;; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1021/jm00071a009

Reference yield:

: (4S,5R)-3-(tert-butyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-<(1S)-3-(2-pyridyl)-1-hydroxypropyl>oxazolidine

: 150545-00-9
(S)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-3-(2-methyl-propane-2-sulfonyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) TFA, 2.) aq. TFA / 1.) CH₂Cl₂, RT, 1 h, 2.) CH₂Cl₂, RT, 3 h

2: 65.3 percent / HOBt*H₂O, HBTU, N-ethylmorpholine / dimethylformamide / 24 h / Ambient temperature

3: 95.3 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / Ambient temperature

4: 68.1 percent / HOBt*H₂O, HBTU, N-ethylmorpholine / dimethylformamide / 24 h / Ambient temperature

With N-ethylmorpholine;; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a009

Reference yield:

: 150577-70-1
(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-(2-pyridyl)hexane

: 150545-00-9
(S)-2-Benzyl-N-{(S)-1-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-ethyl}-3-(2-methyl-propane-2-sulfonyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 65.3 percent / HOBt*H₂O, HBTU, N-ethylmorpholine / dimethylformamide / 24 h / Ambient temperature

2: 95.3 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h / Ambient temperature

3: 68.1 percent / HOBt*H₂O, HBTU, N-ethylmorpholine / dimethylformamide / 24 h / Ambient temperature

With N-ethylmorpholine;; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a009