ethyl (2-oxo-1,2-diphenylethyl) oxalate

Base Information

• Chemical Name: ethyl (2-oxo-1,2-diphenylethyl) oxalate
• CAS No.: 109562-27-8
• Molecular Formula: C₁₈H₁₆O₅
• Molecular Weight: 312.322
• Mol file: 109562-27-8.mol

Synonyms:ethyl (2-oxo-1,2-diphenylethyl) oxalate

Chemical Property of ethyl (2-oxo-1,2-diphenylethyl) oxalate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ethyl (2-oxo-1,2-diphenylethyl) oxalate

There total 2 articles about ethyl (2-oxo-1,2-diphenylethyl) oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

diazoacetic acid ethyl ester (623-73-4) + desyl bromide (1484-50-0) → ethyl (2-oxo-1,2-diphenylethyl) oxalate (109562-27-8)

Guidance literature:

With oxygen; eosin y; In N,N-dimethyl-formamide; at 20 ℃; for 36h; under 760.051 Torr; Schlenk technique; Irradiation;

DOI:10.1021/acs.orglett.8b02487

Reference yield:

2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) + Ethyl oxalyl chloride (4755-77-5) → ethyl (2-oxo-1,2-diphenylethyl) oxalate (109562-27-8)

Guidance literature:

With xylene;

Reference yield:

ethyl (2-oxo-1,2-diphenylethyl) oxalate (109562-27-8) → 4,5-diphenyl-oxazole-2-carboxylic acid ethyl ester (93729-28-3)

Guidance literature:

With ammonium acetate; acetic acid; at 20 ℃; for 14h; Heating / reflux;

upstream raw materials:

2-hydroxy-2-phenylacetophenone

Ethyl oxalyl chloride

diazoacetic acid ethyl ester

desyl bromide

Downstream raw materials:

4,5-diphenyl-oxazole-2-carboxylic acid ethyl ester