N-[9-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]benzamide

Base Information

Chemical Name:N-[9-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]benzamide
CAS No.:81246-82-4
Molecular Formula:C₃₈H₃₅N₅O₇
Molecular Weight:673.725
Hs Code.:2933599590
DSSTox Substance ID:DTXSID70385255
Mol file:81246-82-4.mol

Synonyms:CBDivE_005827;N-[9-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]benzamide;N6-Benzoyl-5'-O-DMT-adenosine;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]adenosine;SCHEMBL19493362;DTXSID70385255;AKOS040763857;PD157917;FT-0772847;A848823;5??-O-(4,4??-Dimethoxytrityl)-N6-benzoyl adenosine;N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]benzamide;N6-Bz-DMT-Ar;N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-adenosine;5'-O-(4,4'-DiMethoxytrityl)-N6-benzoyl adenosine

Suppliers and Price of N-[9-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5''-DMT-Bz-rA
50mg
$ 60.00

Crysdot
5'-DMT-Bz-rA 95+%
100g
$ 970.00

Crysdot
5'-DMT-Bz-rA 95+%
25g
$ 366.00

Chemenu
N-{9-[(2R,3R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3,4-dihydroxyoxolan-2-yl]-9H-purin-6-yl}benzamide 95%
5g
$ 122.00

Chemenu
N-{9-[(2R,3R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3,4-dihydroxyoxolan-2-yl]-9H-purin-6-yl}benzamide 95%
25g
$ 346.00

Chemenu
N-{9-[(2R,3R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3,4-dihydroxyoxolan-2-yl]-9H-purin-6-yl}benzamide 95%
10g
$ 204.00

Biosynth Carbosynth
N6-Benzoyl-5'-O-DMT-adenosine
25 g
$ 625.00

Biosynth Carbosynth
N6-Benzoyl-5'-O-DMT-adenosine
10 g
$ 300.00

Biosynth Carbosynth
N6-Benzoyl-5'-O-DMT-adenosine
2 g
$ 110.00

Biosynth Carbosynth
N6-Benzoyl-5'-O-DMT-adenosine
5 g
$ 175.00

Total 37 raw suppliers

Chemical Property of N-[9-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]benzamide

Chemical Property:

PKA:7.87±0.43(Predicted)
PSA：150.08000
Density:1.36
LogP:4.79670
Storage Temp.:Store dry at 2-8°C
XLogP3:4.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:11
Exact Mass:673.25364847
Heavy Atom Count:50
Complexity:1050

Purity/Quality:

98%, ^*data from raw suppliers

5''-DMT-Bz-rA ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)NC(=O)C7=CC=CC=C7)O)O

Technology Process of N-[9-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]benzamide

There total 6 articles about N-[9-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.9%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 4546-55-8
N-benzoyladenosine

: 129666-75-7,81246-82-4
6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine

Guidance literature:: With pyridine; at 20 ℃; for 1h;
DOI:10.1016/j.tetasy.2005.07.026

Reference yield: 10.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 4546-55-8
N-benzoyladenosine

: 129666-75-7,81246-82-4
6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine

: 82434-61-5
6-N-benzoyl-9-(3,5-O-bis-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl)adenine

: 96026-73-2
6-N-benzoyl-9-(2,5-O-bis-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl)adenine

Guidance literature:: With pyridine; silver nitrate; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1139/v82-165

Reference yield:

: 5-O-(4,4′-dimethoxytrityl)-D-ribofuranose

: 129666-75-7,81246-82-4
6-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine

Guidance literature:: Multi-step reaction with 2 steps

1: tributylphosphine; 1,1'-azodicarbonyl-dipiperidine / [D₃]acetonitrile / 0.25 h / 20 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / Inert atmosphere

With tributylphosphine; sodium hydride; 1,1'-azodicarbonyl-dipiperidine; In [D₃]acetonitrile; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/chem.201604955