4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenamide

Base Information

Chemical Name:4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenamide
CAS No.:1345879-86-8
Molecular Formula:C₂₄H₂₀F₂N₂O₅
Molecular Weight:454.43
Hs Code.:

Synonyms:4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenamide

Suppliers and Price of 4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenamide

There total 11 articles about 4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.7%

: 376584-62-2
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one

: 1345882-00-9
4-((6-bromo-3-(difluoromethoxy)-2-methoxyphenoxy)methyl)benzamide

: 1345879-86-8
4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenamide

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 - 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 99548-55-7
4-bromo-2-methyl-benzoic acid methyl ester

: 1345879-86-8
4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / 20 °C

2.1: ammonia / methanol / 0.17 h / 0 °C

2.2: 16 h / 20 °C

3.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 80 - 90 °C / Inert atmosphere

With N-Bromosuccinimide; ammonia; potassium acetate; caesium carbonate; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

: 78471-43-9
methyl 4-bromo-2-(bromomethyl)benzoate

: 1345879-86-8
4-[3-difluoromethoxy-2-methoxy-6-(1oxo-2,3-dihydro-1H-isoindol-5-yl)phenoxymethyl]benzenamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / methanol / 0.17 h / 0 °C

1.2: 16 h / 20 °C

2.1: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 70 °C / Inert atmosphere

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 80 - 90 °C / Inert atmosphere

With ammonia; potassium acetate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; N,N-dimethyl-formamide;