N-[3-{2-[bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)amino]-1,3-thiazol-5-yl}-5-(morpholin-4-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

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Chemical Name:N-[3-{2-[bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)amino]-1,3-thiazol-5-yl}-5-(morpholin-4-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine
CAS No.:1312572-93-2
Molecular Formula:C₅₄H₆₁F₃N₆O₃SSi₂
Molecular Weight:987.349
Hs Code.:

Synonyms:N-[3-{2-[bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)amino]-1,3-thiazol-5-yl}-5-(morpholin-4-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

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Chemical Property of N-[3-{2-[bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)amino]-1,3-thiazol-5-yl}-5-(morpholin-4-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

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Technology Process of N-[3-{2-[bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)amino]-1,3-thiazol-5-yl}-5-(morpholin-4-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

There total 8 articles about N-[3-{2-[bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)amino]-1,3-thiazol-5-yl}-5-(morpholin-4-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.8%

: 1312572-92-1
5-[3-amino-5-(morpholin-4-yl)phenyl]-N,N-bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)-1,3-thiazol-2-amine

: 33034-67-2
2-chloro-4-trifluoromethylpyrimidine

: 1312572-93-2
N-[3-{2-[bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)amino]-1,3-thiazol-5-yl}-5-(morpholin-4-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; In 1,4-dioxane; at 100 ℃; for 12h; Inert atmosphere; sealed tube;

Reference yield:

: 3819-88-3
1-fluoro-3-iodo-5-nitrobenzene

: 1312572-93-2
N-[3-{2-[bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)amino]-1,3-thiazol-5-yl}-5-(morpholin-4-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: dimethyl sulfoxide / 0.5 h / 130 °C / microwave

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 0.5 h / 20 - 125 °C / Inert atmosphere; microwave

3: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.5 h / 125 °C / Inert atmosphere; microwaves; sealed tube

4: hydrogen; acetic acid / palladium on activated charcoal / ethyl acetate / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

5: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 12 h / 100 °C / Inert atmosphere; sealed tube

With hydrogen; potassium acetate; sodium carbonate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; palladium diacetate; In 1,4-dioxane; 1,2-dimethoxyethane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1051899-19-4
4-(3-iodo-5-nitrophenyl)-morpholine

: 1312572-93-2
N-[3-{2-[bis(2-{[tert-butyl(diphenyl)silyl]oxy}ethyl)amino]-1,3-thiazol-5-yl}-5-(morpholin-4-yl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 0.5 h / 20 - 125 °C / Inert atmosphere; microwave

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.5 h / 125 °C / Inert atmosphere; microwaves; sealed tube

3: hydrogen; acetic acid / palladium on activated charcoal / ethyl acetate / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

4: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 12 h / 100 °C / Inert atmosphere; sealed tube

With hydrogen; potassium acetate; sodium carbonate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; palladium diacetate; In 1,4-dioxane; 1,2-dimethoxyethane; water; dimethyl sulfoxide; ethyl acetate;