(E)-(S)-4-{(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-[4-(di-tert-butoxy-phosphoryloxy)-phenyl]-propionylamino}-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

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Chemical Name:(E)-(S)-4-{(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-[4-(di-tert-butoxy-phosphoryloxy)-phenyl]-propionylamino}-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester
CAS No.:211186-07-1
Molecular Formula:C₅₉H₇₃N₄O₁₁P
Molecular Weight:1045.22
Hs Code.:

(E)-(S)-4-{(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-[4-(di-tert-butoxy-phosphoryloxy)-phenyl]-propionylamino}-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Synonyms:(E)-(S)-4-{(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-[4-(di-tert-butoxy-phosphoryloxy)-phenyl]-propionylamino}-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

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Chemical Property of (E)-(S)-4-{(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-[4-(di-tert-butoxy-phosphoryloxy)-phenyl]-propionylamino}-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

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Technology Process of (E)-(S)-4-{(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-[4-(di-tert-butoxy-phosphoryloxy)-phenyl]-propionylamino}-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

There total 11 articles about (E)-(S)-4-{(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-[4-(di-tert-butoxy-phosphoryloxy)-phenyl]-propionylamino}-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-(S)-4-{(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-[4-(di-tert-butoxy-phosphanyloxy)-phenyl]-propionylamino}-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

: 211186-07-1
(E)-(S)-4-{(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-[4-(di-tert-butoxy-phosphoryloxy)-phenyl]-propionylamino}-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1021/jm9800696

Reference yield:

: 5545-54-0
N-(benzyloxycarbonyl)-O-(1,1-dimethylethyl)-L-tyrosine

: 211186-07-1
(E)-(S)-4-{(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-[4-(di-tert-butoxy-phosphoryloxy)-phenyl]-propionylamino}-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: toluene / 1 h / 23 °C

2: tetrahydrofuran / 23 °C

3: H₂ / 10percent Pd/C / methanol / 5 h

4: tetrahydrofuran / 23 °C

5: 93 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 1.5 h / 23 °C

6: 63 percent / tetrahydrofuran / 23 °C

7: 83 percent / TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

8: tetrazole / tetrahydrofuran / 2 h / 23 °C

9: 0.22 g / m-CPBA / tetrahydrofuran; CH₂Cl₂ / 0.5 h / 0 °C

With 1H-tetrazole; hydrogen; titanium tetrachloride; 3-chloro-benzenecarboperoxoic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/jm9800696

Reference yield:

: 211185-98-7
{(S)-2-(4-tert-Butoxy-phenyl)-1-[(S)-1-hydroxymethyl-3-(trityl-carbamoyl)-propylcarbamoyl]-ethyl}-carbamic acid benzyl ester

: 211186-07-1
(E)-(S)-4-{(S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-[4-(di-tert-butoxy-phosphoryloxy)-phenyl]-propionylamino}-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 10percent Pd/C / methanol / 5 h

2: tetrahydrofuran / 23 °C

3: 93 percent / o-iodoxybenzoic acid / dimethylsulfoxide / 1.5 h / 23 °C

4: 63 percent / tetrahydrofuran / 23 °C

5: 83 percent / TiCl₄ / CH₂Cl₂ / 1 h / 0 °C

6: tetrazole / tetrahydrofuran / 2 h / 23 °C

7: 0.22 g / m-CPBA / tetrahydrofuran; CH₂Cl₂ / 0.5 h / 0 °C

With 1H-tetrazole; hydrogen; titanium tetrachloride; 3-chloro-benzenecarboperoxoic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm9800696