[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea tromethamine salt

Base Information

Chemical Name:[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea tromethamine salt
CAS No.:1079989-98-2
Molecular Formula:C₄H₁₁NO₃*C₂₀H₁₅ClFN₅O₅S₂
Molecular Weight:645.089
Hs Code.:

Synonyms:[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea tromethamine salt

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Chemical Property of [4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea tromethamine salt

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Technology Process of [4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea tromethamine salt

There total 9 articles about [4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea tromethamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

: 936500-94-6
Elinogrel

: 77-86-1
2-amino-2-hydroxymethyl-1,3-propanediol

: 1079989-98-2
[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea tromethamine salt

Guidance literature:: In isopropyl alcohol; for 2h; Product distribution / selectivity;

Reference yield:

: 207346-42-7
2-amino-4,5-difluoro-benzoic acid,methyl ester

: 1079989-98-2
[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea tromethamine salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 3 h / 40 °C

2.1: triethylamine / tetrahydrofuran / 0.42 h

2.2: 2 h / 65 °C

3.1: methanol; sodium methylate / tetrahydrofuran / 4.33 h / 25 - 30 °C

4.1: hydrogenchloride / 1,4-dioxane / 5 - 6 h / 20 - 30 °C

5.1: ethanol; dimethyl sulfoxide / 5.67 h / 25 - 110 °C

6.1: dimethyl sulfoxide / 15 h / 65 °C

7.1: tetrahydrofuran / 2 h

With hydrogenchloride; methanol; sodium methylate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: C₉H₅F₂NO₃

: 1079989-98-2
[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea tromethamine salt

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / N,N-dimethyl-formamide / 20 °C

2: methanol; sodium methylate / tetrahydrofuran / 4.33 h / 25 - 30 °C

3: hydrogenchloride / 1,4-dioxane / 5 - 6 h / 20 - 30 °C

4: ethanol; dimethyl sulfoxide / 5.67 h / 25 - 110 °C

5: dimethyl sulfoxide / 15 h / 65 °C

6: tetrahydrofuran / 2 h

With hydrogenchloride; methanol; sodium methylate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;