(((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide

Base Information

• Chemical Name: (((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide
• CAS No.: 1382900-10-8
• Molecular Formula: C₁₆H₁₈N₆OS₂
• Molecular Weight: 374.491
• Mol file: 1382900-10-8.mol

Synonyms:(((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide

Chemical Property of (((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide

There total 2 articles about (((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C18H20N4O2S2 (1382900-07-3) → (((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide (1382900-10-8)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; for 4h; Reflux;

DOI:10.1007/s00044-012-0092-0

Reference yield:

5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol (1225196-52-0) → (((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide (1382900-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 4 h / Reflux

2: hydrazine hydrate; acetic acid / ethanol / 4 h / Reflux

With hydrazine hydrate; acetic acid; sodium hydroxide; In ethanol;

DOI:10.1007/s00044-012-0092-0

Reference yield: 93.0%

4-chloro-3-methoxybenzaldehyde (13726-16-4) + (((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide (1382900-10-8) → N'-(3-methoxy-4-hydroxybenzylidene)-((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetohydrazid??????? ???????

Guidance literature:

With acetic acid; In ethanol; for 2h; Reflux;

DOI:10.1007/s00044-012-0092-0

upstream raw materials:

5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

C₁₈H₂₀N₄O₂S₂

Downstream raw materials:

N'-(3,4-dimethoxybenzylidene)-((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetohydrazide

N'-(4-chlorobenzylidene)-((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetohydrazide

N'-(4-hydroxybenzylidene)-((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetohydrazide???????????????????????

N'-(3-nitrobenzylidene)-((4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazol-3-ylthio)acetohydrazide??????????????????