5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

Base Information

• Chemical Name: 5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol
• CAS No.: 1225196-52-0
• Molecular Formula: C₁₄H₁₄N₄S₂
• Molecular Weight: 302.424
• Mol file: 1225196-52-0.mol

Synonyms:5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

Chemical Property of 5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol

There total 1 articles about 5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-isopropyl-1,3-thiazole-2-carbohydrazide (1198603-88-1) + phenyl isothiocyanate (103-72-0) → 5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol (1225196-52-0)

Guidance literature:

4-isopropyl-1,3-thiazole-2-carbohydrazide; phenyl isothiocyanate; In ethanol; for 4h; Reflux;

With sodium hydroxide; for 3h; Reflux;

With hydrogenchloride; In water; at 20 ℃; pH=3 - 4;

DOI:10.1016/j.ejmech.2010.01.045

Reference yield: 85.0%

5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol (1225196-52-0) + ethyl bromoacetate (105-36-2) → C18H20N4O2S2 (1382900-07-3)

Guidance literature:

With sodium hydroxide; In ethanol; for 4h; Reflux;

DOI:10.1007/s00044-012-0092-0

Reference yield: 71.0%

5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol (1225196-52-0) + methyl iodide (74-88-4) → 3-(4-isopropylthiazol-2-yl)-5-methylthio-4-phenyl-4H-1,2,4-triazole (1225196-53-1)

Guidance literature:

5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol; With ethanol; sodium; at 20 ℃; for 0.5h;

methyl iodide; In ethanol; for 4h; Reflux;

DOI:10.1016/j.ejmech.2010.01.045

upstream raw materials:

4-isopropyl-1,3-thiazole-2-carbohydrazide

phenyl isothiocyanate

Downstream raw materials:

3-(4-isopropylthiazol-2-yl)-5-methylthio-4-phenyl-4H-1,2,4-triazole

3-(4-isopropyl thiazol-2-yl)-4-phenyl-5-((5-phenyl-1,3,4-oxadiazol-2-yl) methylthio)-4H-1,2,4-triazole

3-((5-(chloromethyl)-1,3,4-oxadiazol-2-yl)methylthio)-5-(4-isopropylthiazol-2-yl)-4-phenyl-4H-1,2,4-triazole

3-(4-isopropylthiazol-2-yl)-5-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methylthio)-4-phenyl-4H-1,2,4-triazole