2S-N-(2''-methyl-4'',5''-dimethoxy-8''naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

Base Information

Chemical Name:2S-N-(2''-methyl-4'',5''-dimethoxy-8''naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane
CAS No.:1206475-86-6
Molecular Formula:C₂₄H₂₉NO₄
Molecular Weight:395.499
Hs Code.:

Synonyms:2S-N-(2''-methyl-4'',5''-dimethoxy-8''naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

Suppliers and Price of 2S-N-(2''-methyl-4'',5''-dimethoxy-8''naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2S-N-(2''-methyl-4'',5''-dimethoxy-8''naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2S-N-(2''-methyl-4'',5''-dimethoxy-8''naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

There total 3 articles about 2S-N-(2''-methyl-4'',5''-dimethoxy-8''naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 104371-22-4
(2S)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

: 177971-26-5
1-bromo-4,5-dimethoxy-7-methylnaphthalene

: 1206475-86-6
2S-N-(2''-methyl-4'',5''-dimethoxy-8''naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110 ℃; for 36h; Inert atmosphere;
DOI:10.1021/ja9097687

Reference yield:

: 882657-86-5
4,5-dimethoxy-7-methyl-naphthalen-1-ylamine

: 18917-77-6
(3,5-dimethoxyphenyl)acetone

: 1206475-97-9
(2R)-N-(2''-methyl-4'',5''-dimethoxy-8''-naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

: 1206475-86-6
2S-N-(2''-methyl-4'',5''-dimethoxy-8''naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

Guidance literature:: With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; C₅₄H₄₉O₄P; In tert-butyl methyl ether; at 40 ℃; Reagent/catalyst; Solvent; Temperature; Overall yield = 78 %; Overall yield = 0.31 g; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1002/adsc.201600472

Reference yield:

: t-butyl (1,8-dimethoxy-3-methylnaphthalene-5-yl)carbamate

: 1206475-97-9
(2R)-N-(2''-methyl-4'',5''-dimethoxy-8''-naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

: 1206475-86-6
2S-N-(2''-methyl-4'',5''-dimethoxy-8''naphthyl)-1-(3',5'-dimethoxyphenyl)-2-aminopropane

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

2: diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; C₅₄H₄₉O₄P / tert-butyl methyl ether / 40 °C / Molecular sieve; Inert atmosphere

With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; C₅₄H₄₉O₄P; trifluoroacetic acid; In dichloromethane; tert-butyl methyl ether;
DOI:10.1002/adsc.201600472