Technology Process of SuNO-Adip-Lys(εAhx-Nps)-OBu-t
There total 6 articles about SuNO-Adip-Lys(εAhx-Nps)-OBu-t which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dicyclohexyl-carbodiimide;
In
tetrahydrofuran;
2 h, 0 deg C => 2 h, r.t.;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / 1-hydroxybenzotriazole, N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide HCl / tetrahydrofuran; various solvent(s) / 1 h, 0 deg C => 6 h, r.t.
2: 92 percent / H2 / Pd/C / methanol; acetic acid / 4 h / Ambient temperature
3: 99 percent / 1-hydroxybenzotriazole, N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide HCl / tetrahydrofuran; various solvent(s) / 2 h, 0 deg C => 2 h, r.t.
4: 88 percent / NaOH (1 M) / dioxane; H2O / 1 h / Ambient temperature
5: 71 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 2 h, 0 deg C => 2 h, r.t.
With
sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / 1-hydroxybenzotriazole, N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide HCl / tetrahydrofuran; various solvent(s) / 1 h, 0 deg C => 6 h, r.t.
2: 92 percent / H2 / Pd/C / methanol; acetic acid / 4 h / Ambient temperature
3: 99 percent / 1-hydroxybenzotriazole, N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide HCl / tetrahydrofuran; various solvent(s) / 2 h, 0 deg C => 2 h, r.t.
4: 88 percent / NaOH (1 M) / dioxane; H2O / 1 h / Ambient temperature
5: 71 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 2 h, 0 deg C => 2 h, r.t.
With
sodium hydroxide; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; acetic acid;
