C₈H₇N₃O₃

Base Information

• Chemical Name: C₈H₇N₃O₃
• CAS No.: 1618636-69-3
• Molecular Formula: C₈H₇N₃O₃
• Molecular Weight: 193.162
• Mol file: 1618636-69-3.mol

Synonyms:C₈H₇N₃O₃

Chemical Property of C₈H₇N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₈H₇N₃O₃

There total 5 articles about C₈H₇N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C9H9N3O3 (1618636-68-2) → C8H7N3O3 (1618636-69-3)

Guidance literature:

With potassium hydroxide; In methanol; for 5h; Reflux;

DOI:10.1039/c4ob00923a

Reference yield:

methyl 2-amino-3-(hydroxymethyl)benzoate (253120-48-8) → C8H7N3O3 (1618636-69-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; sodium nitrite; sodium azide / water / 20 °C

2: potassium hydroxide / methanol / 5 h / Reflux

With hydrogenchloride; sodium azide; potassium hydroxide; sodium nitrite; In methanol; water;

DOI:10.1039/c4ob00923a

Reference yield:

methyl 3-(bromomethyl)-2-nitrobenzoate (132874-06-7) → C8H7N3O3 (1618636-69-3)

Guidance literature:

Multi-step reaction with 4 steps

1: silver(II) sulfate / 1,4-dioxane; water / 3 h / Reflux

2: zinc; acetic acid / dichloromethane / 5 h / 20 °C

3: hydrogenchloride; sodium nitrite; sodium azide / water / 20 °C

4: potassium hydroxide / methanol / 5 h / Reflux

With hydrogenchloride; sodium azide; silver(II) sulfate; acetic acid; potassium hydroxide; zinc; sodium nitrite; In 1,4-dioxane; methanol; dichloromethane; water;

DOI:10.1039/c4ob00923a

upstream raw materials:

methyl 3-methyl-2-nitrobenzoate

methyl 3-(bromomethyl)-2-nitrobenzoate

C₉H₉NO₅

methyl 2-amino-3-(hydroxymethyl)benzoate

Downstream raw materials:

C₁₇H₂₅N₅O₄

C₃₂H₃₈N₈O₅