(+/-)-4-<1,1-difluoro-2-(1,1-dimethylethoxy)-2-oxoethyl>-α-aminobenzenepropanoic acid phenylmethyl ester p-toluenesulfonate

Base Information

Chemical Name:(+/-)-4-<1,1-difluoro-2-(1,1-dimethylethoxy)-2-oxoethyl>-α-aminobenzenepropanoic acid phenylmethyl ester p-toluenesulfonate
CAS No.:127152-83-4
Molecular Formula:C₇H₈O₃S*C₂₂H₂₅F₂NO₄
Molecular Weight:577.646
Hs Code.:

Synonyms:(+/-)-4-<1,1-difluoro-2-(1,1-dimethylethoxy)-2-oxoethyl>-α-aminobenzenepropanoic acid phenylmethyl ester p-toluenesulfonate

Suppliers and Price of (+/-)-4-<1,1-difluoro-2-(1,1-dimethylethoxy)-2-oxoethyl>-α-aminobenzenepropanoic acid phenylmethyl ester p-toluenesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-4-<1,1-difluoro-2-(1,1-dimethylethoxy)-2-oxoethyl>-α-aminobenzenepropanoic acid phenylmethyl ester p-toluenesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-4-<1,1-difluoro-2-(1,1-dimethylethoxy)-2-oxoethyl>-α-aminobenzenepropanoic acid phenylmethyl ester p-toluenesulfonate

There total 4 articles about (+/-)-4-<1,1-difluoro-2-(1,1-dimethylethoxy)-2-oxoethyl>-α-aminobenzenepropanoic acid phenylmethyl ester p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 127152-73-2
4-<1,1-difluoro-2-(1,1-dimethylethoxy)-2-oxoethyl>-α-<(diphenylmethylene)amino>benzenepropanoic acid phenylmethyl ester

: 104-15-4
toluene-4-sulfonic acid

: 127152-83-4
(+/-)-4-<1,1-difluoro-2-(1,1-dimethylethoxy)-2-oxoethyl>-α-aminobenzenepropanoic acid phenylmethyl ester p-toluenesulfonate

Guidance literature:: In water; acetonitrile; for 2h; Ambient temperature;
DOI:10.1021/jm00107a037

Reference yield:

: 5524-56-1
ethyl 2-p-tolyl-2-oxoacetate

: 127152-83-4
(+/-)-4-<1,1-difluoro-2-(1,1-dimethylethoxy)-2-oxoethyl>-α-aminobenzenepropanoic acid phenylmethyl ester p-toluenesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / (dimethylamido)sulfur trifluoride (DAST) / 0 - 20 °C

2: 84 percent / 5 N aq. KOH / acetonitrile / 1 h / Ambient temperature

3: oxalyl chloride, DMF / toluene / 20 h / Ambient temperature

4: DMF / toluene / 24 h / Ambient temperature

5: 73 percent / N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / Heating

6: 1.) lithium diisopropylamide / 1.) THF, HMPA, -78 deg C, 15 min, 2.) from -78 deg C to RT, 2 h

7: 70 percent / acetonitrile; H₂O / 2 h / Ambient temperature

With potassium hydroxide; N-Bromosuccinimide; Perbenzoic acid; oxalyl dichloride; (dimethylamido)sulfur trifluoride; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrachloromethane; water; toluene; acetonitrile;
DOI:10.1021/jm00107a037

Reference yield:

: 131323-06-3
α,α-difluoro-4-methylbenzeneacetic acid ethyl ester

: 127152-83-4
(+/-)-4-<1,1-difluoro-2-(1,1-dimethylethoxy)-2-oxoethyl>-α-aminobenzenepropanoic acid phenylmethyl ester p-toluenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / 5 N aq. KOH / acetonitrile / 1 h / Ambient temperature

2: oxalyl chloride, DMF / toluene / 20 h / Ambient temperature

3: DMF / toluene / 24 h / Ambient temperature

4: 73 percent / N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / Heating

5: 1.) lithium diisopropylamide / 1.) THF, HMPA, -78 deg C, 15 min, 2.) from -78 deg C to RT, 2 h

6: 70 percent / acetonitrile; H₂O / 2 h / Ambient temperature

With potassium hydroxide; N-Bromosuccinimide; Perbenzoic acid; oxalyl dichloride; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrachloromethane; water; toluene; acetonitrile;
DOI:10.1021/jm00107a037