6-bromomethyl-4-(4-fluoro-phenyl)-4-methyl-2-thiazol-2-yl-4H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

Base Information

Chemical Name:6-bromomethyl-4-(4-fluoro-phenyl)-4-methyl-2-thiazol-2-yl-4H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester
CAS No.:1461666-07-8
Molecular Formula:C₂₈H₃₃FN₄O₆S
Molecular Weight:572.658
Hs Code.:

Synonyms:6-bromomethyl-4-(4-fluoro-phenyl)-4-methyl-2-thiazol-2-yl-4H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

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Chemical Property of 6-bromomethyl-4-(4-fluoro-phenyl)-4-methyl-2-thiazol-2-yl-4H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

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Technology Process of 6-bromomethyl-4-(4-fluoro-phenyl)-4-methyl-2-thiazol-2-yl-4H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

There total 6 articles about 6-bromomethyl-4-(4-fluoro-phenyl)-4-methyl-2-thiazol-2-yl-4H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1461666-06-7
6-bromomethyl-4-(4-fluoro-phenyl)-4-methyl-2-thiazol-2-yl-4H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

: 119111-66-9
1-methylamino-cyclopropanecarboxylic acid methyl ester

: 1461666-07-8
6-bromomethyl-4-(4-fluoro-phenyl)-4-methyl-2-thiazol-2-yl-4H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 3h;

Reference yield:

: 1461666-04-5
4-(4-fluoro-phenyl)-4,6-dimethyl-2-thiazol-2-yl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

: 1461666-07-8
6-bromomethyl-4-(4-fluoro-phenyl)-4-methyl-2-thiazol-2-yl-4H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / dichloromethane

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 50 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 105-45-3
acetoacetic acid methyl ester

: 1461666-07-8
6-bromomethyl-4-(4-fluoro-phenyl)-4-methyl-2-thiazol-2-yl-4H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: indium(III) triflate / o-xylene / 2 h / 120 °C

2: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 1.5 h / 120 °C

3: dmap / dichloromethane

4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 50 °C

5: potassium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C

With indium(III) triflate; dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydrogencarbonate; potassium carbonate; In 1-methyl-pyrrolidin-2-one; tetrachloromethane; dichloromethane; o-xylene; N,N-dimethyl-formamide;