Cyclopropanecarboxylic acid, 1-(methylamino)-, methyl ester (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 1-(methylamino)-, methyl ester (9CI)
• CAS No.: 119111-66-9
• Molecular Formula: C6H11 N O2
• Molecular Weight: 129.159
• Mol file: 119111-66-9.mol

Synonyms:Cyclopropanecarboxylic acid, 1-(methylamino)-, methyl ester (9CI)

Chemical Property of Cyclopropanecarboxylic acid, 1-(methylamino)-, methyl ester (9CI)

Chemical Property:

• PSA: 38.33000
• LogP: 0.30230

Purity/Quality:

99% ，98% ^*data from raw suppliers

Methyl1-(methylamino)cyclopropane-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 1-(methylamino)-, methyl ester (9CI)

There total 5 articles about Cyclopropanecarboxylic acid, 1-(methylamino)-, methyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Methyl 1-(N-benzyloxycarbonyl-N-methyl)aminocyclopropane-1-carboxylic acid (210576-30-0) → 1-methylamino-cyclopropanecarboxylic acid methyl ester (119111-66-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 1.5h; under 1140 Torr; Ambient temperature;

DOI:10.1016/S0014-827X(98)00005-6

Reference yield:

methyl 1-(((benzyloxy)carbonyl)amino)cyclopropane-1-carboxylate (84677-05-4) → 1-methylamino-cyclopropanecarboxylic acid methyl ester (119111-66-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 38 percent / Ag₂O / dimethylformamide / 96 h / 50 - 60 °C

2: H₂ / 5percent Pd/C / ethanol / 1.5 h / 1140 Torr / Ambient temperature

With hydrogen; silver(l) oxide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/S0014-827X(98)00005-6

Reference yield:

methyl 1-(N-methylamino)cyclopropanecarboxylate hydrochloride (99324-93-3) → 1-methylamino-cyclopropanecarboxylic acid methyl ester (119111-66-9)

Guidance literature:

With potassium carbonate; In diethyl ether; water; Yield given; Ambient temperature;

DOI:10.1021/jo00269a014

upstream raw materials:

methyl 1-(N-methylamino)cyclopropanecarboxylate hydrochloride

Methyl 1-(N-benzyloxycarbonyl-N-methyl)aminocyclopropane-1-carboxylic acid

methyl 1-(((benzyloxy)carbonyl)amino)cyclopropane-1-carboxylate

methyl 1-((tert-butoxycarbonyl)(methyl)amino)cyclopropane-1-carboxylate

Downstream raw materials:

ethene

3-methylamino-2(5H)furanone

6-bromomethyl-4-(4-fluoro-phenyl)-4-methyl-2-thiazol-2-yl-4H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-methyl ester

Refernces

• 1、 Vaidyanathan, Ganesan,Wilson, Joseph W.. "Reaction of Cyclopropanamines with Hypochlorite". . p. 1815 - 1820. Retrieved 2007/10/02.