[(4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide)]

Base Information

• Chemical Name: [(4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide)]
• CAS No.: 1287761-01-6
• Molecular Formula: C₂₆H₂₄F₃N₅O₃S
• Molecular Weight: 543.569

Synonyms:[(4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide)]

Chemical Property of [(4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide)]

Chemical Property:

Purity/Quality:

98%+ ^*data from raw suppliers

PTUPB 98.82% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-(5-Phenyl-3-[3-[3-(4-trifluoromethyl-phenyl)-ureido]-propyl]-pyrazol-1-yl) benzenesulfonamide is used as a PTUPB; COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence.

Technology Process of [(4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide)]

There total 6 articles about [(4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide)] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-[5-phenyl-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]-propyl ammonium chloride + p-trifluoromethyl-phenylisocyanate (1548-13-6) → [(4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide)] (1287761-01-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jm2001376

Reference yield: 85.0%

→ [(4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide)] (1287761-01-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

4-[3-(3-hydroxypropyl)-5-phenyl-1H-pyrazol-1-yl]benzenesulfonamide → [(4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide)] (1287761-01-6)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

2: sodium azide / 1,4-dioxane; water / 6 h / Inert atmosphere; Reflux

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

With sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm2001376

upstream raw materials:

p-trifluoromethyl-phenylisocyanate

4-[3-(3-azidopropyl)-5-phenyl-pyrazol-1-yl]-benzenesulfonamide

4-hydrazinobenzene-1-sulfonamide hydrochloride

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