trans-4-t-butyl-1-[1-(pivaloyloxymethyl)ethenyl]cyclohexanecarboxylic acid

Base Information

Chemical Name:trans-4-t-butyl-1-[1-(pivaloyloxymethyl)ethenyl]cyclohexanecarboxylic acid
CAS No.:468773-91-3
Molecular Formula:C₁₉H₃₂O₄
Molecular Weight:324.461
Hs Code.:

Synonyms:trans-4-t-butyl-1-[1-(pivaloyloxymethyl)ethenyl]cyclohexanecarboxylic acid

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Chemical Property of trans-4-t-butyl-1-[1-(pivaloyloxymethyl)ethenyl]cyclohexanecarboxylic acid

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Technology Process of trans-4-t-butyl-1-[1-(pivaloyloxymethyl)ethenyl]cyclohexanecarboxylic acid

There total 4 articles about trans-4-t-butyl-1-[1-(pivaloyloxymethyl)ethenyl]cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 468773-87-7
trans-4-t-butyl-1-[1-(pivaloyloxymethyl)ethenyl]cyclohexanecarbaldehyde

: 468773-91-3
trans-4-t-butyl-1-[1-(pivaloyloxymethyl)ethenyl]cyclohexanecarboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(02)00403-9

Reference yield:

: 3282-30-2
pivaloyl chloride

: 468773-91-3
trans-4-t-butyl-1-[1-(pivaloyloxymethyl)ethenyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 94 percent / pyridine / 20 °C

2.1: Et₂AlCl / CH₂Cl₂; hexane / -60 °C

3.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

3.2: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -60 - 20 °C

4.1: 93 percent / 2-methyl-2-butene; NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 1 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; diethylaluminium chloride; In tetrahydrofuran; pyridine; hexane; dichloromethane; water; tert-butyl alcohol; 3.2: Swern oxidation;
DOI:10.1016/S0040-4020(02)00403-9

Reference yield:

: 468773-80-0
2-(4-t-butyl)cyclohexylidene-3-trimethylsilylprop-1-yl pivalate

: 468773-91-3
trans-4-t-butyl-1-[1-(pivaloyloxymethyl)ethenyl]cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₂AlCl / CH₂Cl₂; hexane / -60 °C

2.1: tetrabutylammonium fluoride / tetrahydrofuran / 20 °C

2.2: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -60 - 20 °C

3.1: 93 percent / 2-methyl-2-butene; NaH₂PO₄*2H₂O; NaClO₂ / 2-methyl-propan-2-ol; H₂O / 1 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; tetrabutyl ammonium fluoride; diethylaluminium chloride; In tetrahydrofuran; hexane; dichloromethane; water; tert-butyl alcohol; 2.2: Swern oxidation;
DOI:10.1016/S0040-4020(02)00403-9