5-tert-butyl-3-{2-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-oxazol-4-yl}-isoxazole

Base Information

Chemical Name:5-tert-butyl-3-{2-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-oxazol-4-yl}-isoxazole
CAS No.:1196103-30-6
Molecular Formula:C₁₉H₂₁ClN₂O₄S
Molecular Weight:408.906
Hs Code.:

Synonyms:5-tert-butyl-3-{2-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-oxazol-4-yl}-isoxazole

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Chemical Property of 5-tert-butyl-3-{2-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-oxazol-4-yl}-isoxazole

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Technology Process of 5-tert-butyl-3-{2-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-oxazol-4-yl}-isoxazole

There total 5 articles about 5-tert-butyl-3-{2-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-oxazol-4-yl}-isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 1196103-89-5
2-(4-chloro-benzenesulfonyl)-2-methyl-propionic acid 2-(5-tert-butyl-isoxazol-3-yl)-2-oxo-ethyl ester

: 1196103-30-6
5-tert-butyl-3-{2-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-oxazol-4-yl}-isoxazole

Guidance literature:: With acetamide; boron trifluoride diethyl etherate; In o-xylene; at 220 ℃; for 7h; Microwave irradiation;

Reference yield: 6.0%

: 60-35-5
acetamide

: 1196103-89-5
2-(4-chloro-benzenesulfonyl)-2-methyl-propionic acid 2-(5-tert-butyl-isoxazol-3-yl)-2-oxo-ethyl ester

: 1196103-30-6
5-tert-butyl-3-{2-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-oxazol-4-yl}-isoxazole

Guidance literature:: With boron trifluoride diethyl etherate; at 220 ℃; for 7h; Microwave irradiaton;

Reference yield:

: 91252-54-9
5-tert-butylisoxazole-3-carboxylic acid ethyl ester

: 1196103-30-6
5-tert-butyl-3-{2-[1-(4-chloro-benzenesulfonyl)-1-methyl-ethyl]-oxazol-4-yl}-isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: methyllithium / diethyl ether; tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

2: sodium carbonate / N,N-dimethyl-formamide / 0.27 h / 20 °C / Inert atmosphere

3: boron trifluoride diethyl etherate / 7 h / 220 °C / Microwave irradiaton

With boron trifluoride diethyl etherate; methyllithium; sodium carbonate; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;